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Page 1
High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling.
Gruber T, Lechner F, Murat C, Contreras RE, Sanchez-Quant E, Miok V, Makris K, Le Thuc O, González-García I, García-Clave E, Althammer F, Krabichler Q, DeCamp LM, Jones RG, Lutter D, Williams RH, Pfluger PT, Müller TD, Woods SC, Pospisilik JA, Martinez-Jimenez CP, Tschöp MH, Grinevich V, García-Cáceres C. Gruber T, et al. Among authors: contreras re. Cell Rep. 2023 Oct 31;42(10):113305. doi: 10.1016/j.celrep.2023.113305. Cell Rep. 2023. PMID: 37864798 Free PMC article.
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. Quiñones M, et al. Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6. Nat Commun. 2018. PMID: 30143607 Free PMC article.
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT. Pfuhlmann K, et al. Among authors: contreras re. Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146. Epub 2018 Aug 28. Diabetes. 2018. PMID: 30158241
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C. Gruber T, et al. Among authors: contreras re. Cell Metab. 2021 Jun 1;33(6):1155-1170.e10. doi: 10.1016/j.cmet.2021.04.007. Epub 2021 May 4. Cell Metab. 2021. PMID: 33951475 Free PMC article.
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C. González-García I, et al. Among authors: contreras re. Cell Metab. 2023 Mar 7;35(3):438-455.e7. doi: 10.1016/j.cmet.2023.02.004. Cell Metab. 2023. PMID: 36889283 Free PMC article.
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.
Contreras RE, Gruber T, González-García I, Schriever SC, De Angelis M, Mallet N, Bernecker M, Legutko B, Kabra D, Schmidt M, Tschöp MH, Gutierrez-Aguilar R, Mellor J, García-Cáceres C, Pfluger PT. Contreras RE, et al. Mol Metab. 2024 Dec;90:102033. doi: 10.1016/j.molmet.2024.102033. Epub 2024 Sep 19. Mol Metab. 2024. PMID: 39304061 Free PMC article.
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.
Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT. Pfuhlmann K, et al. Among authors: contreras re. Diabetes. 2019 Mar;68(3):676. doi: 10.2337/db19-er03a. Epub 2019 Jan 11. Diabetes. 2019. PMID: 30635274 Free PMC article. No abstract available.