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Page 1
Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction.
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB. Kefala Stavridi A, et al. Among authors: barboule n. Nucleic Acids Res. 2023 Nov 27;51(21):11732-11747. doi: 10.1093/nar/gkad863. Nucleic Acids Res. 2023. PMID: 37870477 Free PMC article.
PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Andreani J, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK. Seif-El-Dahan M, et al. Among authors: barboule n. Sci Adv. 2023 Jun 2;9(22):eadg2834. doi: 10.1126/sciadv.adg2834. Epub 2023 May 31. Sci Adv. 2023. PMID: 37256950 Free PMC article.
XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nemoz C, Ropars V, Frit P, Gontier A, Drevet P, Yu J, Guerois R, Pitois A, Comte A, Delteil C, Barboule N, Legrand P, Baconnais S, Yin Y, Tadi S, Barbet-Massin E, Berger I, Le Cam E, Modesti M, Rothenberg E, Calsou P, Charbonnier JB. Nemoz C, et al. Among authors: barboule n. Nat Struct Mol Biol. 2018 Oct;25(10):971-980. doi: 10.1038/s41594-018-0133-6. Epub 2018 Oct 5. Nat Struct Mol Biol. 2018. PMID: 30291363 Free PMC article.
Alternative end-joining pathway(s): bricolage at DNA breaks.
Frit P, Barboule N, Yuan Y, Gomez D, Calsou P. Frit P, et al. Among authors: barboule n. DNA Repair (Amst). 2014 May;17:81-97. doi: 10.1016/j.dnarep.2014.02.007. Epub 2014 Mar 6. DNA Repair (Amst). 2014. PMID: 24613763 Free article. Review.
20 results