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Page 1
De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expression.
Tangudu NK, Buj R, Wang H, Wang J, Cole AR, Uboveja A, Fang R, Amalric A, Sajjakulnukit P, Lyons MA, Cooper K, Hempel N, Snyder NW, Lyssiotis CA, Chandran UR, Aird KM. Tangudu NK, et al. Among authors: hempel n. bioRxiv [Preprint]. 2023 Sep 23:2023.07.15.549149. doi: 10.1101/2023.07.15.549149. bioRxiv. 2023. Update in: Cancer Res Commun. 2024 May 2;4(5):1174-1188. doi: 10.1158/2767-9764.CRC-23-0450 PMID: 37503050 Free PMC article. Updated. Preprint.
A multiple-oscillator mechanism underlies antigen-induced Ca2+ oscillations in Jurkat T-cells.
Benson JC, Romito O, Abdelnaby AE, Xin P, Pathak T, Weir SE, Kirk V, Castaneda F, Yoast RE, Emrich SM, Tang PW, Yule DI, Hempel N, Potier-Cartereau M, Sneyd J, Trebak M. Benson JC, et al. Among authors: hempel n. J Biol Chem. 2023 Nov;299(11):105310. doi: 10.1016/j.jbc.2023.105310. Epub 2023 Sep 29. J Biol Chem. 2023. PMID: 37778728 Free PMC article.
Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancer.
Javed Z, Shin DH, Pan W, White SR, Kim YS, Elhaw AT, Kamlapurkar S, Cheng YY, Benson JC, Abdelnaby AE, Phaëton R, Wang HG, Yang S, Sullivan MLG, St Croix CM, Watkins SC, Mullett SJ, Gelhaus SL, Lee N, Coffman LG, Aird KM, Trebak M, Mythreye K, Walter V, Hempel N. Javed Z, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Jan 24:2023.09.20.558501. doi: 10.1101/2023.09.20.558501. bioRxiv. 2024. Update in: EMBO Rep. 2024 Oct;25(10):4281-4310. doi: 10.1038/s44319-024-00232-4 PMID: 37790404 Free PMC article. Updated. Preprint.
ATR promotes mTORC1 activity via de novo cholesterol synthesis.
Tangudu NK, Grumet AN, Fang R, Buj R, Cole AR, Uboveja A, Amalric A, Yang B, Huang Z, Happe C, Sun M, Gelhaus SL, MacDonald ML, Hempel N, Snyder NW, Kedziora KM, Valvezan AJ, Aird KM. Tangudu NK, et al. Among authors: hempel n. bioRxiv [Preprint]. 2024 Oct 24:2023.10.27.564195. doi: 10.1101/2023.10.27.564195. bioRxiv. 2024. PMID: 37961201 Free PMC article. Preprint.
Carcinoma-associated mesenchymal stem cells promote ovarian cancer heterogeneity and metastasis through mitochondrial transfer.
Frisbie L, Pressimone C, Dyer E, Baruwal R, Garcia G, St Croix C, Watkins S, Calderone M, Gorecki G, Javed Z, Atiya HI, Hempel N, Pearson A, Coffman LG. Frisbie L, et al. Among authors: hempel n. Cell Rep. 2024 Aug 27;43(8):114551. doi: 10.1016/j.celrep.2024.114551. Epub 2024 Jul 26. Cell Rep. 2024. PMID: 39067022 Free PMC article.
Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production.
Sharrow AC, Megill E, Chen AJ, Farooqi A, Tangudu NK, Uboveja A, McGonigal S, Hempel N, Snyder NW, Buckanovich RJ, Aird KM. Sharrow AC, et al. Among authors: hempel n. Mol Metab. 2024 Nov;89:102031. doi: 10.1016/j.molmet.2024.102031. Epub 2024 Sep 19. Mol Metab. 2024. PMID: 39304063 Free PMC article.
101 results