Al-Karmalawy AA - Search Results

1

Design and synthesis of novel pyrazolopyrimidine candidates as promising EGFR-T790M inhibitors and apoptosis inducers.

Gaber AA, Sharaky M, Elmaaty AA, Hammouda MM, Mourad AA, Elkhawaga SY, Mokhtar MM, Abouzied AS, Mourad MA, Al-Karmalawy AA. Gaber AA, et al. Future Med Chem. 2023 Oct;15(19):1773-1790. doi: 10.4155/fmc-2023-0156. Epub 2023 Oct 26. Future Med Chem. 2023. PMID: 37882053

2

Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.

Al-Karmalawy AA, Nafie MS, Shaldam MA, Elmaaty AA, Antar SA, El-Hamaky AA, Saleh MA, Elkamhawy A, Tawfik HO. Al-Karmalawy AA, et al. J Med Chem. 2023 Jan 12;66(1):777-792. doi: 10.1021/acs.jmedchem.2c01668. Epub 2022 Dec 16. J Med Chem. 2023. PMID: 36525642

3

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.

Mourad MAE, Abo Elmaaty A, Zaki I, Mourad AAE, Hofni A, Khodir AE, Aboubakr EM, Elkamhawy A, Roh EJ, Al-Karmalawy AA. Mourad MAE, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2205043. doi: 10.1080/14756366.2023.2205043. J Enzyme Inhib Med Chem. 2023. PMID: 37165800 Free PMC article.

4

Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments.

Al-Karmalawy AA, Rashed M, Sharaky M, Abulkhair HS, Hammouda MM, Tawfik HO, Shaldam MA. Al-Karmalawy AA, et al. Eur J Med Chem. 2023 Nov 5;259:115661. doi: 10.1016/j.ejmech.2023.115661. Epub 2023 Jul 18. Eur J Med Chem. 2023. PMID: 37482023

5

Ligand-based design and synthesis of N'-Benzylidene-3,4-dimethoxybenzohydrazide derivatives as potential antimicrobial agents; evaluation by in vitro, in vivo, and in silico approaches with SAR studies.

Ezz Eldin RR, Saleh MA, Alotaibi MH, Alsuair RK, Alzahrani YA, Alshehri FA, Mohamed AF, Hafez SM, Althoqapy AA, Khirala SK, Amin MM, A F Y, AbdElwahab AH, Alesawy MS, Elmaaty AA, Al-Karmalawy AA. Ezz Eldin RR, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1098-1119. doi: 10.1080/14756366.2022.2063282. J Enzyme Inhib Med Chem. 2022. PMID: 35430934 Free PMC article.

6

Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies.

Hammouda MM, Elmaaty AA, Nafie MS, Abdel-Motaal M, Mohamed NS, Tantawy MA, Belal A, Alnajjar R, Eldehna WM, Al-Karmalawy AA. Hammouda MM, et al. Bioorg Chem. 2022 Oct;127:105995. doi: 10.1016/j.bioorg.2022.105995. Epub 2022 Jun 30. Bioorg Chem. 2022. PMID: 35792315

7

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease.

Elagawany M, Elmaaty AA, Mostafa A, Abo Shama NM, Santali EY, Elgendy B, Al-Karmalawy AA. Elagawany M, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2112-2132. doi: 10.1080/14756366.2022.2105322. J Enzyme Inhib Med Chem. 2022. PMID: 35912578 Free PMC article.

8

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR^WT and EGFR^T790M inhibitors.

Al-Warhi T, Al-Karmalawy AA, Elmaaty AA, Alshubramy MA, Abdel-Motaal M, Majrashi TA, Asem M, Nabil A, Eldehna WM, Sharaky M. Al-Warhi T, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):176-191. doi: 10.1080/14756366.2022.2135512. J Enzyme Inhib Med Chem. 2023. PMID: 36317648 Free PMC article.

9

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.

Farouk F, Elmaaty AA, Elkamhawy A, Tawfik HO, Alnajjar R, Abourehab MAS, Saleh MA, Eldehna WM, Al-Karmalawy AA. Farouk F, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2171029. doi: 10.1080/14756366.2023.2171029. J Enzyme Inhib Med Chem. 2023. PMID: 36701269 Free PMC article.

10

Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer.

Abbass EM, Al-Karmalawy AA, Sharaky M, Khattab M, Alzahrani AYA, Hassaballah AI. Abbass EM, et al. Bioorg Chem. 2024 Jan;142:106936. doi: 10.1016/j.bioorg.2023.106936. Epub 2023 Oct 24. Bioorg Chem. 2024. PMID: 37890211

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