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Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
Mourad MAE, Abo Elmaaty A, Zaki I, Mourad AAE, Hofni A, Khodir AE, Aboubakr EM, Elkamhawy A, Roh EJ, Al-Karmalawy AA. Mourad MAE, et al. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2205043. doi: 10.1080/14756366.2023.2205043. J Enzyme Inhib Med Chem. 2023. PMID: 37165800 Free PMC article.
Lead Optimization of BIBR1591 To Improve Its Telomerase Inhibitory Activity: Design and Synthesis of Novel Four Chemical Series with In Silico, In Vitro, and In Vivo Preclinical Assessments.
Al-Karmalawy AA, Mousa MHA, Sharaky M, Mourad MAE, El-Dessouki AM, Hamouda AO, Alnajjar R, Ayed AA, Shaldam MA, Tawfik HO. Al-Karmalawy AA, et al. Among authors: mourad mae. J Med Chem. 2024 Jan 11;67(1):492-512. doi: 10.1021/acs.jmedchem.3c01708. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117230
Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma.
Aly AA, El-Sheref EM, Bakheet MEM, Mourad MAE, Bräse S, Ibrahim MAA, Nieger M, Garvalov BK, Dalby KN, Kaoud TS. Aly AA, et al. Bioorg Chem. 2019 Feb;82:290-305. doi: 10.1016/j.bioorg.2018.10.044. Epub 2018 Oct 23. Bioorg Chem. 2019. PMID: 30396063 Free PMC article.
17 results