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Page 1
Activation of Thoeris antiviral system via SIR2 effector filament assembly.
Tamulaitiene G, Sabonis D, Sasnauskas G, Ruksenaite A, Silanskas A, Avraham C, Ofir G, Sorek R, Zaremba M, Siksnys V. Tamulaitiene G, et al. Among authors: siksnys v. Nature. 2024 Mar;627(8003):431-436. doi: 10.1038/s41586-024-07092-x. Epub 2024 Feb 21. Nature. 2024. PMID: 38383786
Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing.
Bigelyte G, Duchovska B, Zedaveinyte R, Sasnauskas G, Sinkunas T, Dalgediene I, Tamulaitiene G, Silanskas A, Kazlauskas D, Valančauskas L, Madariaga-Marcos J, Seidel R, Siksnys V, Karvelis T. Bigelyte G, et al. Among authors: siksnys v. Nucleic Acids Res. 2024 Apr 12;52(6):3234-3248. doi: 10.1093/nar/gkae016. Nucleic Acids Res. 2024. PMID: 38261981 Free PMC article.
CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes.
Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, Tsuchida CA, Tran RV, Hofman L, Shi H, Wasko KM, Zhou Z, Xia C, Al-Shimary MJ, Patel JR, Thomas VCJX, Pattali R, Kan MJ, Vardapetyan A, Yang A, Lahiri A, Maxwell MF, Murdock AG, Ramit GC, Henderson HR, Calvert RW, Bamert RS, Knott GJ, Lapinaite A, Pausch P, Cofsky JC, Sontheimer EJ, Wiedenheft B, Fineran PC, Brouns SJJ, Sashital DG, Thomas BC, Brown CT, Goltsman DSA, Barrangou R, Siksnys V, Banfield JF, Savage DF, Doudna JA. Adler BA, et al. Among authors: siksnys v. Nucleic Acids Res. 2024 Jan 5;52(D1):D590-D596. doi: 10.1093/nar/gkad890. Nucleic Acids Res. 2024. PMID: 37889041 Free PMC article.
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.
Hino T, Omura SN, Nakagawa R, Togashi T, Takeda SN, Hiramoto T, Tasaka S, Hirano H, Tokuyama T, Uosaki H, Ishiguro S, Kagieva M, Yamano H, Ozaki Y, Motooka D, Mori H, Kirita Y, Kise Y, Itoh Y, Matoba S, Aburatani H, Yachie N, Karvelis T, Siksnys V, Ohmori T, Hoshino A, Nureki O. Hino T, et al. Among authors: siksnys v. Cell. 2023 Oct 26;186(22):4920-4935.e23. doi: 10.1016/j.cell.2023.08.031. Epub 2023 Sep 29. Cell. 2023. PMID: 37776859 Free article.
The energy landscape for R-loop formation by the CRISPR-Cas Cascade complex.
Kauert DJ, Madariaga-Marcos J, Rutkauskas M, Wulfken A, Songailiene I, Sinkunas T, Siksnys V, Seidel R. Kauert DJ, et al. Among authors: siksnys v. Nat Struct Mol Biol. 2023 Jul;30(7):1040-1047. doi: 10.1038/s41594-023-01019-2. Epub 2023 Jul 6. Nat Struct Mol Biol. 2023. PMID: 37415009
TnpB structure reveals minimal functional core of Cas12 nuclease family.
Sasnauskas G, Tamulaitiene G, Druteika G, Carabias A, Silanskas A, Kazlauskas D, Venclovas Č, Montoya G, Karvelis T, Siksnys V. Sasnauskas G, et al. Among authors: siksnys v. Nature. 2023 Apr;616(7956):384-389. doi: 10.1038/s41586-023-05826-x. Epub 2023 Apr 5. Nature. 2023. PMID: 37020015
Mis-annotation of TnpB: case of TaRGET-ABE.
Karvelis T, Siksnys V. Karvelis T, et al. Among authors: siksnys v. Nat Chem Biol. 2023 Mar;19(3):261-262. doi: 10.1038/s41589-022-01242-w. Epub 2023 Feb 16. Nat Chem Biol. 2023. PMID: 36797404 No abstract available.
133 results