Lear TB - Search Results

1

E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.

Lear TB, Boudreau ÁN, Lockwood KC, Chu E, Camarco DP, Cao Q, Nguyen M, Evankovich JW, Finkel T, Liu Y, Chen BB. Lear TB, et al. J Biol Chem. 2023 Dec;299(12):105388. doi: 10.1016/j.jbc.2023.105388. Epub 2023 Oct 27. J Biol Chem. 2023. PMID: 37890782 Free PMC article.

2

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.

Lear TB, Lockwood KC, Ouyang Y, Evankovich JW, Larsen MB, Lin B, Liu Y, Chen BB. Lear TB, et al. J Biol Chem. 2019 Nov 8;294(45):16527-16534. doi: 10.1074/jbc.AC119.010671. Epub 2019 Oct 4. J Biol Chem. 2019. PMID: 31586034 Free PMC article.

3

Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.

Lear TB, Lockwood KC, Larsen M, Tuncer F, Kennerdell JR, Morse C, Valenzi E, Tabib T, Jurczak MJ, Kass DJ, Evankovich JW, Finkel T, Lafyatis R, Liu Y, Chen BB. Lear TB, et al. J Biol Chem. 2020 Mar 27;295(13):4171-4180. doi: 10.1074/jbc.AC119.012066. Epub 2020 Feb 17. J Biol Chem. 2020. PMID: 32071084 Free PMC article.

4

[No title available]

[No authors listed] [No authors listed] PMID: 33506775

5

The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.

Liu Y, Lear T, Iannone O, Shiva S, Corey C, Rajbhandari S, Jerome J, Chen BB, Mallampalli RK. Liu Y, et al. J Biol Chem. 2015 May 8;290(19):11843-52. doi: 10.1074/jbc.M114.629931. Epub 2015 Mar 16. J Biol Chem. 2015. PMID: 25778398 Free PMC article.

6

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.

Han S, Lear TB, Jerome JA, Rajbhandari S, Snavely CA, Gulick DL, Gibson KF, Zou C, Chen BB, Mallampalli RK. Han S, et al. Among authors: lear tb. J Biol Chem. 2015 Jul 17;290(29):18124-18133. doi: 10.1074/jbc.M115.645549. Epub 2015 Jun 2. J Biol Chem. 2015. PMID: 26037928 Free PMC article.

7

Therapeutic targets in fibrotic pathways.

Lear T, Chen BB. Lear T, et al. Cytokine. 2016 Dec;88:193-195. doi: 10.1016/j.cyto.2016.09.008. Epub 2016 Sep 19. Cytokine. 2016. PMID: 27658114 Free PMC article.

8

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

McKelvey AC, Lear TB, Dunn SR, Evankovich J, Londino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, Chen BB. McKelvey AC, et al. Among authors: lear tb. Elife. 2016 Nov 2;5:e18496. doi: 10.7554/eLife.18496. Elife. 2016. PMID: 27805901 Free PMC article.

9

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.

Lear T, Dunn SR, McKelvey AC, Mir A, Evankovich J, Chen BB, Liu Y. Lear T, et al. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C584-C592. doi: 10.1152/ajpcell.00193.2017. Epub 2017 Oct 4. Am J Physiol Cell Physiol. 2017. PMID: 28978524 Free PMC article.

10

KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.

Lear TB, McKelvey AC, Evankovich JW, Rajbhandari S, Coon TA, Dunn SR, Londino JD, McVerry BJ, Zhang Y, Valenzi E, Burton CL, Gordon R, Gingras S, Lockwood KC, Jurczak MJ, Lafyatis R, Shlomchik MJ, Liu Y, Chen BB. Lear TB, et al. JCI Insight. 2019 Oct 3;4(19):e129110. doi: 10.1172/jci.insight.129110. JCI Insight. 2019. PMID: 31578312 Free PMC article.

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