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Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs.
Steinebach C, Bricelj A, Murgai A, Sosič I, Bischof L, Ng YLD, Heim C, Maiwald S, Proj M, Voget R, Feller F, Košmrlj J, Sapozhnikova V, Schmidt A, Zuleeg MR, Lemnitzer P, Mertins P, Hansen FK, Gütschow M, Krönke J, Hartmann MD. Steinebach C, et al. Among authors: hartmann md. J Med Chem. 2023 Nov 9;66(21):14513-14543. doi: 10.1021/acs.jmedchem.3c00851. Epub 2023 Oct 30. J Med Chem. 2023. PMID: 37902300 Free PMC article.
Chemical Ligand Space of Cereblon.
Boichenko I, Bär K, Deiss S, Heim C, Albrecht R, Lupas AN, Hernandez Alvarez B, Hartmann MD. Boichenko I, et al. Among authors: hartmann md. ACS Omega. 2018 Sep 14;3(9):11163-11171. doi: 10.1021/acsomega.8b00959. eCollection 2018 Sep 30. ACS Omega. 2018. PMID: 31459225 Free PMC article.
Replacing the phthalimide core in thalidomide with benzotriazole.
Krasavin M, Bubyrev A, Kazantsev A, Heim C, Maiwald S, Zhukovsky D, Dar'in D, Hartmann MD, Bunev A. Krasavin M, et al. Among authors: hartmann md. J Enzyme Inhib Med Chem. 2022 Dec;37(1):527-530. doi: 10.1080/14756366.2021.2024525. J Enzyme Inhib Med Chem. 2022. PMID: 35220840 Free PMC article.
74 results