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Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.
Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M. Romanelli E, et al. Among authors: simons m. Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275. Nat Commun. 2016. PMID: 27848954 Free PMC article.
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis.
Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Berghoff SA, et al. Among authors: simons m. Nat Neurosci. 2021 Jan;24(1):47-60. doi: 10.1038/s41593-020-00757-6. Epub 2020 Dec 21. Nat Neurosci. 2021. PMID: 33349711 Free PMC article.
Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination.
Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M. Bosch-Queralt M, et al. Among authors: simons m. Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7. Epub 2021 Feb 18. Nat Metab. 2021. PMID: 33619376 Free PMC article.
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia.
Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, Tahirovic S. Colombo A, et al. Among authors: simons m. Nat Commun. 2021 Feb 24;12(1):1158. doi: 10.1038/s41467-021-21428-5. Nat Commun. 2021. PMID: 33627648 Free PMC article.
1,545 results