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Quantifying and mitigating motor phenotypes induced by antisense oligonucleotides in the central nervous system.
Moazami MP, Rembetsy-Brown JM, Sarli SL, McEachern HR, Wang F, Ohara M, Wagh A, Kelly K, Krishnamurthy PM, Weiss A, Marosfoi M, King RM, Motwani M, Gray-Edwards H, Fitzgerald KA, Brown RH, Watts JK. Moazami MP, et al. Among authors: watts jk. Mol Ther. 2024 Dec 4;32(12):4401-4417. doi: 10.1016/j.ymthe.2024.10.024. Epub 2024 Oct 28. Mol Ther. 2024. PMID: 39460376 Free PMC article.
CASCADES, a novel SOX2 super-enhancer-associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma.
Shahzad U, Nikolopoulos M, Li C, Johnston M, Wang JJ, Sabha N, Varn FS, Riemenschneider A, Krumholtz S, Krishnamurthy PM, Smith CA, Karamchandani J, Watts JK, Verhaak RGW, Gallo M, Rutka JT, Das S. Shahzad U, et al. Among authors: watts jk. Mol Oncol. 2024 Sep 25. doi: 10.1002/1878-0261.13735. Online ahead of print. Mol Oncol. 2024. PMID: 39323013 Free article.
Increasing intracellular dNTP levels improves prime editing efficiency.
Liu P, Ponnienselvan K, Nyalile T, Oikemus S, Joynt AT, Iyer S, Kelly K, Guo D, Kyawe PP, Vanderleeden E, Redick SD, Huang L, Chen Z, Lee JM, Schiffer CA, Harlan DM, Wang JP, Emerson CP Jr, Lawson ND, Watts JK, Sontheimer EJ, Luban J, Wolfe SA. Liu P, et al. Among authors: watts jk. Nat Biotechnol. 2024 Sep 25. doi: 10.1038/s41587-024-02405-x. Online ahead of print. Nat Biotechnol. 2024. PMID: 39322763
Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity.
Fakih HH, Tang Q, Summers A, Shin M, Buchwald JE, Gagnon R, Hariharan VN, Echeverria D, Cooper DA, Watts JK, Khvorova A, Sleiman HF. Fakih HH, et al. Among authors: watts jk. Mol Ther Nucleic Acids. 2023 Nov 17;34:102080. doi: 10.1016/j.omtn.2023.102080. eCollection 2023 Dec 12. Mol Ther Nucleic Acids. 2023. PMID: 38089931 Free PMC article.
70 results