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Structural and functional studies reveal the molecular basis of substrate promiscuity of a glycosyltransferase originating from a major agricultural pest.
Arriaza RH, Abiskaroon B, Patel M, Daneshian L, Kluza A, Snoeck S, Watkins MB, Hopkins JB, Van Leeuwen T, Grbic M, Grbic V, Borowski T, Chruszcz M. Arriaza RH, et al. J Biol Chem. 2023 Dec;299(12):105421. doi: 10.1016/j.jbc.2023.105421. Epub 2023 Nov 1. J Biol Chem. 2023. PMID: 37923139 Free PMC article.
Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928.
Prakash R, Goodlett DW, Varghese S, Andrys J, Gbadamosi FA, Arriaza RH, Patel M, Tiwari PB, Borowski T, Chruszcz M, Shimizu LS, Upadhyay G. Prakash R, et al. Among authors: arriaza rh. Bioorg Med Chem. 2023 Feb 1;79:117171. doi: 10.1016/j.bmc.2023.117171. Epub 2023 Jan 13. Bioorg Med Chem. 2023. PMID: 36680947 Free PMC article.
Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction.
Selvanesan BC, Varghese S, Andrys-Olek J, Arriaza RH, Prakash R, Tiwari PB, Hupalo D, Gusev Y, Patel MN, Contente S, Sanda M, Uren A, Wilkerson MD, Dalgard CL, Shimizu LS, Chruszcz M, Borowski T, Upadhyay G. Selvanesan BC, et al. Among authors: arriaza rh. Cancer Lett. 2023 Apr 1;558:216094. doi: 10.1016/j.canlet.2023.216094. Epub 2023 Feb 16. Cancer Lett. 2023. PMID: 36805500 Free PMC article.