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A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a nonhemophilic state.
Teranishi-Ikawa Y, Soeda T, Koga H, Yamaguchi K, Kato K, Esaki K, Asanuma K, Funaki M, Ichiki M, Ikuta Y, Ito S, Joyashiki E, Komatsu SI, Muto A, Nishimura K, Okuda M, Sanada H, Sato M, Shibahara N, Wakabayashi T, Yamaguchi K, Matsusaki A, Sampei Z, Shiraiwa H, Konishi H, Kawabe Y, Hattori K, Kitazawa T, Igawa T. Teranishi-Ikawa Y, et al. Among authors: yamaguchi k. J Thromb Haemost. 2024 Feb;22(2):430-440. doi: 10.1016/j.jtha.2023.09.034. Epub 2023 Nov 6. J Thromb Haemost. 2024. PMID: 37940048 Free article.
Selective SGLT2 inhibition by tofogliflozin reduces renal glucose reabsorption under hyperglycemic but not under hypo- or euglycemic conditions in rats.
Nagata T, Fukazawa M, Honda K, Yata T, Kawai M, Yamane M, Murao N, Yamaguchi K, Kato M, Mitsui T, Suzuki Y, Ikeda S, Kawabe Y. Nagata T, et al. Among authors: yamaguchi k. Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E414-23. doi: 10.1152/ajpendo.00545.2012. Epub 2012 Dec 18. Am J Physiol Endocrinol Metab. 2013. PMID: 23249697 Free article.
In vitro profiling of the metabolism and drug-drug interaction of tofogliflozin, a potent and highly specific sodium-glucose co-transporter 2 inhibitor, using human liver microsomes, human hepatocytes, and recombinant human CYP.
Yamane M, Kawashima K, Yamaguchi K, Nagao S, Sato M, Suzuki M, Honda K, Hagita H, Kuhlmann O, Poirier A, Fowler S, Funk C, Simon S, Aso Y, Ikeda S, Ishigai M. Yamane M, et al. Among authors: yamaguchi k. Xenobiotica. 2015 Mar;45(3):230-8. doi: 10.3109/00498254.2014.976296. Epub 2014 Oct 28. Xenobiotica. 2015. PMID: 25350082
C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.
Ohtake Y, Sato T, Matsuoka H, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Higuchi T, Murakata M, Morikawa K, Shimma N, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S. Ohtake Y, et al. Among authors: yamaguchi k. Bioorg Med Chem. 2012 Jul 1;20(13):4117-27. doi: 10.1016/j.bmc.2012.04.053. Epub 2012 May 4. Bioorg Med Chem. 2012. PMID: 22652255
Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures.
Shimizu K, Kawase A, Haneishi T, Kato Y, Kinoshita K, Ohmori M, Furuta Y, Emura T, Kato N, Mitsui T, Yamaguchi K, Morita K, Sekiguchi N, Yamamoto T, Matsushita T, Shimaoka S, Sugita A, Morikawa K. Shimizu K, et al. Among authors: yamaguchi k. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3323-9. doi: 10.1016/j.bmcl.2006.03.014. Epub 2006 Apr 21. Bioorg Med Chem Lett. 2006. PMID: 16630723
Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
Ohtake Y, Sato T, Kobayashi T, Nishimoto M, Taka N, Takano K, Yamamoto K, Ohmori M, Yamaguchi M, Takami K, Yeu SY, Ahn KH, Matsuoka H, Morikawa K, Suzuki M, Hagita H, Ozawa K, Yamaguchi K, Kato M, Ikeda S. Ohtake Y, et al. Among authors: yamaguchi m, yamaguchi k. J Med Chem. 2012 Sep 13;55(17):7828-40. doi: 10.1021/jm300884k. Epub 2012 Aug 28. J Med Chem. 2012. PMID: 22889351
7,731 results