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Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients.
Zaikos TD, Terry VH, Sebastian Kettinger NT, Lubow J, Painter MM, Virgilio MC, Neevel A, Taschuk F, Onafuwa-Nuga A, McNamara LA, Riddell J 4th, Bixby D, Markowitz N, Collins KL. Zaikos TD, et al. Among authors: taschuk f. Cell Rep. 2018 Dec 26;25(13):3759-3773.e9. doi: 10.1016/j.celrep.2018.11.104. Cell Rep. 2018. PMID: 30590047 Free article.
CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.
Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J IV, Bixby D, Markowitz N, Morrison SJ, Collins KL. Sebastian NT, et al. Among authors: taschuk f. PLoS Pathog. 2017 Jul 21;13(7):e1006509. doi: 10.1371/journal.ppat.1006509. eCollection 2017 Jul. PLoS Pathog. 2017. PMID: 28732051 Free PMC article.