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Page 1
Cell lineage analysis with somatic mutations reveals late divergence of neuronal cell types and cortical areas in human cerebral cortex.
Kim SN, Viswanadham VV, Doan RN, Dou Y, Bizzotto S, Khoshkhoo S, Huang AY, Yeh R, Chhouk B, Truong A, Chappell KM, Beaudin M, Barton A, Akula SK, Rento L, Lodato M, Ganz J, Szeto RA, Li P, Tsai JW, Hill RS, Park PJ, Walsh CA. Kim SN, et al. Among authors: szeto ra. bioRxiv [Preprint]. 2023 Nov 6:2023.11.06.565899. doi: 10.1101/2023.11.06.565899. bioRxiv. 2023. PMID: 37986891 Free PMC article. Preprint.
SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.
Mesci P, de Souza JS, Martin-Sancho L, Macia A, Saleh A, Yin X, Snethlage C, Adams JW, Avansini SH, Herai RH, Almenar-Queralt A, Pu Y, Szeto RA, Goldberg G, Bruck PT, Papes F, Chanda SK, Muotri AR. Mesci P, et al. Among authors: szeto ra. PLoS Biol. 2022 Nov 3;20(11):e3001845. doi: 10.1371/journal.pbio.3001845. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36327326 Free PMC article.
Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content.
Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sánchez-Sánchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araújo BMP, Velho PENF, Haddad GG, Muotri AR. Papes F, et al. Among authors: szeto ra. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. Nat Commun. 2022. PMID: 35501322 Free PMC article.
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment.
Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, Buchanan J, Preissl S, Wang A, Negraes PD, Szeto RA, Herai RH, Huseynov A, Ferraz MSA, Borges FS, Kihara AH, Byrne A, Marin M, Vollmers C, Brooks AN, Lautz JD, Semendeferi K, Shapiro B, Yeo GW, Smith SEP, Green RE, Muotri AR. Trujillo CA, et al. Among authors: szeto ra. Science. 2021 Feb 12;371(6530):eaax2537. doi: 10.1126/science.aax2537. Science. 2021. PMID: 33574182 Free PMC article.