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126 results

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Page 1
Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation.
Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I. Torre D, et al. Among authors: guccione e. Mol Cell. 2023 Dec 7;83(23):4255-4271.e9. doi: 10.1016/j.molcel.2023.10.036. Epub 2023 Nov 22. Mol Cell. 2023. PMID: 37995687 Free PMC article.
A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer.
Mzoughi S, Schwarz M, Wang X, Demircioglu D, Ulukaya G, Mohammed K, Tullio FD, Company C, Dramaretska Y, Leushacke M, Giotti B, Lannagan T, Lozano-Ojalvo D, Hasson D, Tsankov AM, Sansom OJ, Marine JC, Barker N, Gargiulo G, Guccione E. Mzoughi S, et al. Among authors: guccione e. bioRxiv [Preprint]. 2023 Dec 10:2023.12.10.570854. doi: 10.1101/2023.12.10.570854. bioRxiv. 2023. PMID: 38106050 Free PMC article. Preprint.
Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis.
Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. Sinha S, et al. Among authors: guccione e. Nat Commun. 2023 May 8;14(1):2651. doi: 10.1038/s41467-023-38406-8. Nat Commun. 2023. PMID: 37156770 Free PMC article.
Precision targeting of β-catenin induces tumor reprogramming and immunity in hepatocellular cancers.
Monga S, Lehrich B, Delgado E, Yasaka T, Liu S, Cao C, Liu Y, Taheri M, Guan X, Koeppen H, Singh S, Liu JJ, Singh-Varma A, Krutsenko Y, Poddar M, Hitchens T, Foley L, Liang B, Rialdi A, Rai R, Patel P, Riley M, Bell A, Raeman R, Dadali T, Luke J, Guccione E, Ebrahimkhani M, Lujambio A, Chen X, Maier M, Wang Y, Broom W, Tao J. Monga S, et al. Among authors: guccione e. Res Sq [Preprint]. 2024 Dec 12:rs.3.rs-5494074. doi: 10.21203/rs.3.rs-5494074/v1. Res Sq. 2024. PMID: 39711542 Free PMC article. Preprint.
Steering research on mRNA splicing in cancer towards clinical translation.
Anczukow O, Allain FH, Angarola BL, Black DL, Brooks AN, Cheng C, Conesa A, Crosse EI, Eyras E, Guccione E, Lu SX, Neugebauer KM, Sehgal P, Song X, Tothova Z, Valcárcel J, Weeks KM, Yeo GW, Thomas-Tikhonenko A. Anczukow O, et al. Among authors: guccione e. Nat Rev Cancer. 2024 Dec;24(12):887-905. doi: 10.1038/s41568-024-00750-2. Epub 2024 Oct 9. Nat Rev Cancer. 2024. PMID: 39384951 Free PMC article. Review.
A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress.
Hoang PM, Torre D, Jaynes P, Ho J, Mohammed K, Alvstad E, Lam WY, Khanchandani V, Lee JM, Toh CMC, Lee RX, Anbuselvan A, Lee S, Sebra RP, Martin J Walsh, Marazzi I, Kappei D, Guccione E, Jeyasekharan AD. Hoang PM, et al. Among authors: guccione e. Sci Adv. 2024 Jun 7;10(23):eadm9589. doi: 10.1126/sciadv.adm9589. Epub 2024 Jun 5. Sci Adv. 2024. PMID: 38838142 Free article.
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.
Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, Hickman AR, Mao W, Thakar T, Vaitsiankova A, Huang JW, Cuella-Martin R, Hayward SB, Kesner JS, Ghasemzadeh A, Nambiar TS, Ho P, Rialdi A, Hebrard M, Li Y, Gao J, Gopinath S, Adeleke OA, Venters BJ, Drake CG, Baer R, Izar B, Guccione E, Keogh MC, Guerois R, Sun L, Lu C, Califano A, Ciccia A. Leuzzi G, et al. Among authors: guccione e. Cell. 2024 Feb 15;187(4):861-881.e32. doi: 10.1016/j.cell.2024.01.008. Epub 2024 Jan 31. Cell. 2024. PMID: 38301646
RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
Maurin M, Ranjouri M, Megino-Luque C, Newberg JY, Du D, Martin K, Miner RE 3rd, Prater MS, Wee DKB, Centeno B, Pruett-Miller SM, Stewart P, Fleming JB, Yu X, Bravo-Cordero JJ, Guccione E, Black MA, Mann KM. Maurin M, et al. Among authors: guccione e. Nat Commun. 2023 Dec 19;14(1):8444. doi: 10.1038/s41467-023-44126-w. Nat Commun. 2023. PMID: 38114498 Free PMC article.
126 results