Wang Z - Search Results

1

MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis.

Liu S, Perez P, Sun X, Chen K, Fatirkhorani R, Mammadova J, Wang Z. Liu S, et al. Among authors: wang z. Cell Death Differ. 2024 Jan;31(1):40-52. doi: 10.1038/s41418-023-01237-7. Epub 2023 Nov 23. Cell Death Differ. 2024. PMID: 37996483 Free PMC article.

2

MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis.

Liu S, Liu H, Johnston A, Hanna-Addams S, Reynoso E, Xiang Y, Wang Z. Liu S, et al. Among authors: wang z. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7450-E7459. doi: 10.1073/pnas.1707531114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827318 Free PMC article.

3

Necroptosis: MLKL Polymerization.

Johnston A, Wang Z. Johnston A, et al. Among authors: wang z. J Nat Sci. 2018 Jul;4(7):e513. J Nat Sci. 2018. PMID: 30294675 Free PMC article.

4

CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis.

Hanna-Addams S, Liu S, Liu H, Chen S, Wang Z. Hanna-Addams S, et al. Among authors: wang z. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):1962-1970. doi: 10.1073/pnas.1917112117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932442 Free PMC article.

5

Necroptosis-blocking compound NBC1 targets heat shock protein 70 to inhibit MLKL polymerization and necroptosis.

Johnston AN, Ma Y, Liu H, Liu S, Hanna-Addams S, Chen S, Chen C, Wang Z. Johnston AN, et al. Among authors: wang z. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6521-6530. doi: 10.1073/pnas.1916503117. Epub 2020 Mar 10. Proc Natl Acad Sci U S A. 2020. PMID: 32156734 Free PMC article.

6

HSP70 promotes MLKL polymerization and necroptosis.

Johnston AN, Wang Z. Johnston AN, et al. Among authors: wang z. Mol Cell Oncol. 2020 Jul 14;7(5):1791561. doi: 10.1080/23723556.2020.1791561. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32944645 Free PMC article.

7

RIPK1 dephosphorylation and kinase activation by PPP1R3G/PP1γ promote apoptosis and necroptosis.

Du J, Xiang Y, Liu H, Liu S, Kumar A, Xing C, Wang Z. Du J, et al. Among authors: wang z. Nat Commun. 2021 Dec 3;12(1):7067. doi: 10.1038/s41467-021-27367-5. Nat Commun. 2021. PMID: 34862394 Free PMC article.

8

The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways.

Wang Z, Jiang H, Chen S, Du F, Wang X. Wang Z, et al. Among authors: wang x. Cell. 2012 Jan 20;148(1-2):228-43. doi: 10.1016/j.cell.2011.11.030. Cell. 2012. PMID: 22265414 Free article.

9

Thioredoxin-1 actively maintains the pseudokinase MLKL in a reduced state to suppress disulfide bond-dependent MLKL polymer formation and necroptosis.

Reynoso E, Liu H, Li L, Yuan AL, Chen S, Wang Z. Reynoso E, et al. Among authors: wang z. J Biol Chem. 2017 Oct 20;292(42):17514-17524. doi: 10.1074/jbc.M117.799353. Epub 2017 Sep 6. J Biol Chem. 2017. PMID: 28878015 Free PMC article.

10

Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions.

Du J, Wang Z. Du J, et al. Among authors: wang z. Biomedicines. 2024 Jul 9;12(7):1525. doi: 10.3390/biomedicines12071525. Biomedicines. 2024. PMID: 39062098 Free PMC article. Review.

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