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A versatile platform for locus-scale genome rewriting and verification.
Brosh R, Laurent JM, Ordoñez R, Huang E, Hogan MS, Hitchcock AM, Mitchell LA, Pinglay S, Cadley JA, Luther RD, Truong DM, Boeke JD, Maurano MT. Brosh R, et al. Among authors: boeke jd. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2023952118. doi: 10.1073/pnas.2023952118. Proc Natl Acad Sci U S A. 2021. PMID: 33649239 Free PMC article.
De novo assembly and delivery to mouse cells of a 101 kb functional human gene.
Mitchell LA, McCulloch LH, Pinglay S, Berger H, Bosco N, Brosh R, Bulajić M, Huang E, Hogan MS, Martin JA, Mazzoni EO, Davoli T, Maurano MT, Boeke JD. Mitchell LA, et al. Among authors: boeke jd. Genetics. 2021 May 17;218(1):iyab038. doi: 10.1093/genetics/iyab038. Genetics. 2021. PMID: 33742653 Free PMC article.
Synthetic regulatory reconstitution reveals principles of mammalian Hox cluster regulation.
Pinglay S, Bulajić M, Rahe DP, Huang E, Brosh R, Mamrak NE, King BR, German S, Cadley JA, Rieber L, Easo N, Lionnet T, Mahony S, Maurano MT, Holt LJ, Mazzoni EO, Boeke JD. Pinglay S, et al. Among authors: boeke jd. Science. 2022 Jul;377(6601):eabk2820. doi: 10.1126/science.abk2820. Epub 2022 Jul 1. Science. 2022. PMID: 35771912 Free PMC article.
CREEPY: CRISPR-mediated editing of synthetic episomes in yeast.
Zhao Y, Coelho C, Lauer S, Majewski M, Laurent JM, Brosh R, Boeke JD. Zhao Y, et al. Among authors: boeke jd. Nucleic Acids Res. 2023 Jul 21;51(13):e72. doi: 10.1093/nar/gkad491. Nucleic Acids Res. 2023. PMID: 37326023 Free PMC article.
Mouse genome rewriting and tailoring of three important disease loci.
Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska AM, Ordoñez R, Ribeiro-Dos-Santos AM, Carrau L, Damani-Yokota P, Yeung ST, Khairallah C, Vela Gartner A, Chalhoub N, Huang E, Ashe HJ, Khanna KM, Maurano MT, Kim SY, tenOever BR, Boeke JD. Zhang W, et al. Among authors: boeke jd. Nature. 2023 Nov;623(7986):423-431. doi: 10.1038/s41586-023-06675-4. Epub 2023 Nov 1. Nature. 2023. PMID: 37914927 Free PMC article.
On the genetic basis of tail-loss evolution in humans and apes.
Xia B, Zhang W, Zhao G, Zhang X, Bai J, Brosh R, Wudzinska A, Huang E, Ashe H, Ellis G, Pour M, Zhao Y, Coelho C, Zhu Y, Miller A, Dasen JS, Maurano MT, Kim SY, Boeke JD, Yanai I. Xia B, et al. Among authors: boeke jd. Nature. 2024 Feb;626(8001):1042-1048. doi: 10.1038/s41586-024-07095-8. Epub 2024 Feb 28. Nature. 2024. PMID: 38418917 Free PMC article.
Synthetic reversed sequences reveal default genomic states.
Camellato BR, Brosh R, Ashe HJ, Maurano MT, Boeke JD. Camellato BR, et al. Among authors: boeke jd. Nature. 2024 Apr;628(8007):373-380. doi: 10.1038/s41586-024-07128-2. Epub 2024 Mar 6. Nature. 2024. PMID: 38448583 Free PMC article.
422 results