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PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. Liu P, et al. Among authors: guo j. Cancer Discov. 2015 Nov;5(11):1194-209. doi: 10.1158/2159-8290.CD-15-0460. Epub 2015 Aug 20. Cancer Discov. 2015. PMID: 26293922 Free PMC article.
Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.
Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Zhang J, et al. Among authors: guo j. Mol Cell. 2016 Jun 16;62(6):929-942. doi: 10.1016/j.molcel.2016.04.023. Epub 2016 May 26. Mol Cell. 2016. PMID: 27237051 Free PMC article.
pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner.
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG Jr, Wei W. Guo J, et al. Science. 2016 Aug 26;353(6302):929-32. doi: 10.1126/science.aad5755. Science. 2016. PMID: 27563096 Free PMC article.
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