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Page 1
Discovery and evaluation of novel SHIP-1 inhibitors.
Miao J, Lin J, Dong J, Amarasinghe O, Mason ER, Chu S, Qu Z, Cullers CC, Putt KS, Zhang ZY. Miao J, et al. Among authors: amarasinghe o. Bioorg Med Chem. 2024 Nov 15;114:117965. doi: 10.1016/j.bmc.2024.117965. Epub 2024 Oct 19. Bioorg Med Chem. 2024. PMID: 39454561
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.
Jesudason CD, Mason ER, Chu S, Oblak AL, Javens-Wolfe J, Moussaif M, Durst G, Hipskind P, Beck DE, Dong J, Amarasinghe O, Zhang ZY, Hamdani AK, Singhal K, Mesecar AD, Souza S, Jacobson M, Salvo JD, Soni DM, Kandasamy M, Masters AR, Quinney SK, Doolen S, Huhe H, Rizzo SJS, Lamb BT, Palkowitz AD, Richardson TI. Jesudason CD, et al. Among authors: amarasinghe o. Alzheimers Dement (N Y). 2023 Nov 17;9(4):e12429. doi: 10.1002/trc2.12429. eCollection 2023 Oct-Dec. Alzheimers Dement (N Y). 2023. PMID: 38023622 Free PMC article.
PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY. Bai Y, et al. Among authors: amarasinghe o. Autophagy. 2023 May;19(5):1562-1581. doi: 10.1080/15548627.2022.2140558. Epub 2022 Nov 7. Autophagy. 2023. PMID: 36300783 Free PMC article.
Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
Li Q, Bai Y, Lyle LT, Yu G, Amarasinghe O, Nguele Meke F, Carlock C, Zhang ZY. Li Q, et al. Among authors: amarasinghe o. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20538-20548. doi: 10.1073/pnas.2002964117. Epub 2020 Aug 11. Proc Natl Acad Sci U S A. 2020. PMID: 32788364 Free PMC article.