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Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma.
Liu Y, Zhan Z, Kang Z, Li M, Lv Y, Li S, Tong L, Feng F, Li Y, Zhang M, Xue Y, Chen Y, Zhang T, Song P, Su Y, Shen Y, Sun Y, Yang X, Chen Y, Yao S, Yang H, Wang C, Geng M, Li W, Duan W, Xie H, Ding J. Liu Y, et al. Among authors: yang x, yang h. Acta Pharm Sin B. 2023 Dec;13(12):4748-4764. doi: 10.1016/j.apsb.2023.09.009. Epub 2023 Sep 22. Acta Pharm Sin B. 2023. PMID: 38045044 Free PMC article.
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance.
Wang LM, Wang P, Chen XM, Yang H, Song SS, Song Z, Jia L, Chen HD, Bao XB, Guo N, Huan XJ, Xi Y, Shen YY, Yang XY, Su Y, Sun YM, Gao YL, Chen Y, Ding J, Lang JY, Miao ZH, Zhang A, He JX. Wang LM, et al. EMBO Mol Med. 2023 Mar 8;15(3):e16235. doi: 10.15252/emmm.202216235. Epub 2023 Jan 18. EMBO Mol Med. 2023. PMID: 36652375 Free PMC article.
Integrated omics profiling reveals systemic dysregulation and potential biomarkers in the blood of patients with neuromyelitis optica spectrum disorders.
Xie Z, Zhou Q, Hu J, He L, Meng H, Liu X, Sun G, Luo Z, Feng Y, Li L, Chu X, Du C, Yang D, Yang X, Zhang J, Ge C, Zhang X, Chen S, Geng M. Xie Z, et al. Among authors: yang d, yang x. J Transl Med. 2024 Nov 1;22(1):989. doi: 10.1186/s12967-024-05801-8. J Transl Med. 2024. PMID: 39487546 Free PMC article.
Sodium oligomannate disrupts the adherence of Ribhigh bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice.
Wang X, Xie Z, Yuan J, Jin E, Lian W, Chang S, Sun G, Feng Z, Xu H, Du C, Yang X, Xia A, Qiu J, Zhang Q, Lin F, Liu J, Li L, Du X, Xiao Z, Yi Z, Luo Z, Ge C, Li R, Zheng M, Jiang Y, Wang T, Zhang J, Guo Q, Geng M. Wang X, et al. Among authors: yang x. Cell Discov. 2024 Nov 19;10(1):115. doi: 10.1038/s41421-024-00725-5. Cell Discov. 2024. PMID: 39557828 Free PMC article.
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