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Cigarette smoke preferentially induces full length ACE2 expression in differentiated primary human airway cultures but does not alter the efficiency of cellular SARS-CoV-2 infection.
Porter LM, Guo W, Crozier TW, Greenwood EJ, Ortmann B, Kottmann D, Nathan JA, Mahadeva R, Lehner PJ, McCaughan F. Porter LM, et al. Among authors: mccaughan f. Heliyon. 2023 Mar;9(3):e14383. doi: 10.1016/j.heliyon.2023.e14383. Epub 2023 Mar 11. Heliyon. 2023. PMID: 36938474 Free PMC article.
Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion.
Crozier TWM, Greenwood EJD, Williamson JC, Guo W, Porter LM, Gabaev I, Teixeira-Silva A, Grice GL, Wickenhagen A, Stanton RJ, Wang ECY, Wilson SJ, Matheson NJ, Nathan JA, McCaughan F, Lehner PJ. Crozier TWM, et al. Among authors: mccaughan f. Wellcome Open Res. 2022 Sep 7;7:224. doi: 10.12688/wellcomeopenres.17946.1. eCollection 2022. Wellcome Open Res. 2022. PMID: 36483314 Free PMC article.
In vitro platform to model the function of ionocytes in the human airway epithelium.
Vilà-González M, Pinte L, Fradique R, Causa E, Kool H, Rodrat M, Morell CM, Al-Thani M, Porter L, Guo W, Maeshima R, Hart SL, McCaughan F, Granata A, Sheppard DN, Floto RA, Rawlins EL, Cicuta P, Vallier L. Vilà-González M, et al. Among authors: mccaughan f. Respir Res. 2024 Apr 25;25(1):180. doi: 10.1186/s12931-024-02800-7. Respir Res. 2024. PMID: 38664797 Free PMC article.
Lung cancer in never smokers (LCINS): development of a UK national research strategy.
Khan S, Hatton N, Tough D, Rintoul RC, Pepper C, Calman L, McDonald F, Harris C, Randle A, Turner MC, Haley RA, Rawlinson J, Crosbie PAJ, McCaughan F, Hatton M. Khan S, et al. Among authors: mccaughan f. BJC Rep. 2023 Jul 20;1(1):21. doi: 10.1038/s44276-023-00006-w. BJC Rep. 2023. PMID: 39516402 Free PMC article. Review.
Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind, placebo-controlled, phase 3 trial.
Hardt K, Vandebosch A, Sadoff J, Le Gars M, Truyers C, Lowson D, Van Dromme I, Vingerhoets J, Kamphuis T, Scheper G, Ruiz-Guiñazú J, Faust SN, Spinner CD, Schuitemaker H, Van Hoof J, Douoguih M, Struyf F; ENSEMBLE2 study group. Hardt K, et al. Lancet Infect Dis. 2022 Dec;22(12):1703-1715. doi: 10.1016/S1473-3099(22)00506-0. Epub 2022 Sep 13. Lancet Infect Dis. 2022. PMID: 36113538 Free PMC article. Clinical Trial.
Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters.
Neary M, Box H, Sharp J, Tatham L, Curley P, Herriott J, Kijak E, Arshad U, Hobson JJ, Rajoli R, Pertinez H, Valentijn A, Dhaliwal K, McCaughan F, Rannard SP, Kipar A, Stewart JP, Owen A. Neary M, et al. Among authors: mccaughan f. bioRxiv [Preprint]. 2021 Jul 8:2021.07.08.451654. doi: 10.1101/2021.07.08.451654. bioRxiv. 2021. PMID: 34268511 Free PMC article. Preprint.
Identification of SARS-CoV-2-induced pathways reveals drug repurposing strategies.
Han N, Hwang W, Tzelepis K, Schmerer P, Yankova E, MacMahon M, Lei W, M Katritsis N, Liu A, Felgenhauer U, Schuldt A, Harris R, Chapman K, McCaughan F, Weber F, Kouzarides T. Han N, et al. Among authors: mccaughan f. Sci Adv. 2021 Jun 30;7(27):eabh3032. doi: 10.1126/sciadv.abh3032. Print 2021 Jun. Sci Adv. 2021. PMID: 34193418 Free PMC article.
36 results