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Crimean-Congo hemorrhagic fever virus replicon particle vaccine is safe and elicits functional, non-neutralizing anti-nucleoprotein antibodies and T cell activation in rhesus macaques.
Kleymann A, Karaaslan E, Scholte FEM, Sorvillo TE, Welch SR, Bergeron É, Elser S, Almanzar-Jordan MR, Velazquez E, Genzer SC, Jean SM, Spiropoulou CF, Spengler JR. Kleymann A, et al. Among authors: genzer sc. Antiviral Res. 2025 Jan;233:106045. doi: 10.1016/j.antiviral.2024.106045. Epub 2024 Dec 1. Antiviral Res. 2025. PMID: 39626793
Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M. Welch SR, et al. Among authors: genzer sc. Sci Transl Med. 2024 Nov 20;16(774):eado7034. doi: 10.1126/scitranslmed.ado7034. Epub 2024 Nov 20. Sci Transl Med. 2024. PMID: 39565871
Replicon particle vaccination induces non-neutralizing anti-nucleoprotein antibody-mediated control of Crimean-Congo hemorrhagic fever virus.
Sorvillo TE, Karaaslan E, Scholte FEM, Welch SR, Coleman-McCray JD, Genzer SC, Ritter JM, Hayes HM, Jain S, Pegan SD, Bergeron É, Montgomery JM, Spiropoulou CF, Spengler JR. Sorvillo TE, et al. Among authors: genzer sc. NPJ Vaccines. 2024 May 23;9(1):88. doi: 10.1038/s41541-024-00877-1. NPJ Vaccines. 2024. PMID: 38782933 Free PMC article.
Effect of Adopting a Timothy Hay-based Diet at Weaning or in Adulthood on Urinary Tract Parameters in Strain 13/N Guinea Pigs (Cavia porcellus).
Wier RC, Flietstra TD, Coleman-McCray JD, Genzer SC, Brake ME, Velazquez EM, Forero C, Welch SR, Tansey CM, Condrey JA, Spengler JR. Wier RC, et al. Among authors: genzer sc. J Am Assoc Lab Anim Sci. 2024 Jul 1;63(4):385-396. doi: 10.30802/AALAS-JAALAS-24-000019. Epub 2024 Apr 5. J Am Assoc Lab Anim Sci. 2024. PMID: 38580436 Free PMC article.
Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions.
Scholte FEM, Karaaslan E, O'Neal TJ, Sorvillo TE, Genzer SC, Welch SR, Coleman-McCray JD, Spengler JR, Kainulainen MH, Montgomery JM, Pegan SD, Bergeron E, Spiropoulou CF. Scholte FEM, et al. Among authors: genzer sc. Front Cell Infect Microbiol. 2023 Aug 21;13:1233148. doi: 10.3389/fcimb.2023.1233148. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37671145 Free PMC article.
Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination.
Welch SR, Spengler JR, Genzer SC, Coleman-McCray JD, Harmon JR, Sorvillo TE, Scholte FEM, Rodriguez SE, O'Neal TJ, Ritter JM, Ficarra G, Davies KA, Kainulainen MH, Karaaslan E, Bergeron É, Goldsmith CS, Lo MK, Nichol ST, Montgomery JM, Spiropoulou CF. Welch SR, et al. Among authors: genzer sc. Sci Adv. 2023 Aug 4;9(31):eadh4057. doi: 10.1126/sciadv.adh4057. Epub 2023 Aug 4. Sci Adv. 2023. PMID: 37540755 Free PMC article.
Mouse models of Ebola virus tolerance and lethality: characterization of CD-1 mice infected with wild-type, guinea pig-adapted, or mouse-adapted virus.
Spengler JR, Welch SR, Ritter JM, Harmon JR, Coleman-McCray JD, Genzer SC, Seixas JN, Scholte FEM, Davies KA, Bradfute SB, Montgomery JM, Spiropoulou CF. Spengler JR, et al. Among authors: genzer sc. Antiviral Res. 2023 Feb;210:105496. doi: 10.1016/j.antiviral.2022.105496. Epub 2022 Dec 22. Antiviral Res. 2023. PMID: 36567020
20 results