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174 results

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GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.
Bhattacharya D, Barrile R, Toukam DK, Gawali VS, Kallay L, Ahmed T, Brown H, Rezvanian S, Karve A, Desai PB, Medvedovic M, Wang K, Ionascu D, Harun N, Vallabhapurapu S, Wang C, Qi X, Baschnagel AM, Kritzer JA, Cook JM, Pomeranz Krummel DA, Sengupta S. Bhattacharya D, et al. Among authors: medvedovic m. Cancers (Basel). 2024 Sep 15;16(18):3167. doi: 10.3390/cancers16183167. Cancers (Basel). 2024. PMID: 39335139 Free PMC article.
Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking.
Thorman AW, Reigle J, Chutipongtanate S, Yang J, Shamsaei B, Pilarczyk M, Fazel-Najafabadi M, Adamczak R, Kouril M, Bhatnagar S, Hummel S, Niu W, Morrow AL, Czyzyk-Krzeska MF, McCullumsmith R, Seibel W, Nassar N, Zheng Y, Hildeman DA, Medvedovic M, Herr AB, Meller J. Thorman AW, et al. Among authors: medvedovic m. Sci Adv. 2024 Aug 30;10(35):eadj3010. doi: 10.1126/sciadv.adj3010. Epub 2024 Aug 30. Sci Adv. 2024. PMID: 39213358 Free PMC article.
Coordinated Targeting of S6K1/2 and AXL Disrupts Pyrimidine Biosynthesis in PTEN-Deficient Glioblastoma.
Behrmann CA, Ennis KN, Sarma P, Wetzel C, Clark NA, Von Handorf KM, Vallabhapurapu S, Andreani C, Reigle J, Scaglioni PP, Meller J, Czyzyk-Krzeska MF, Kendler A, Qi X, Sarkaria JN, Medvedovic M, Sengupta S, Dasgupta B, Plas DR. Behrmann CA, et al. Among authors: medvedovic m. Cancer Res Commun. 2024 Aug 1;4(8):2215-2227. doi: 10.1158/2767-9764.CRC-23-0631. Cancer Res Commun. 2024. PMID: 39087397 Free PMC article.
Pathophysiology of hypereosinophilia-associated heart disease.
Sunusi U, Ziegelmeyer B, Osuji I, Medvedovic M, Todd H, Abou-Khalil J, Zimmermann N. Sunusi U, et al. Among authors: medvedovic m. bioRxiv [Preprint]. 2024 Jul 5:2024.07.03.601845. doi: 10.1101/2024.07.03.601845. bioRxiv. 2024. PMID: 39005455 Free PMC article. Preprint.
A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas.
Desai PB, Karve AS, Zawit M, Arora P, Dave N, Awosika J, Li N, Fuhrman B, Medvedovic M, Sallans L, Kendler A, DasGupta B, Plas D, Curry R, Zuccarello M, Chaudhary R, Sengupta S, Wise-Draper TM. Desai PB, et al. Among authors: medvedovic m. Clin Cancer Res. 2024 May 15;30(10):2068-2077. doi: 10.1158/1078-0432.CCR-23-3341. Clin Cancer Res. 2024. PMID: 38530160 Clinical Trial.
MAP3K1 regulates female reproductive tract development.
Kimura E, Mongan M, Xiao B, Christianto A, Wang J, Carreira VS, Bolon B, Zhang X, Burns KA, Biesiada J, Medvedovic M, Puga A, Xia Y. Kimura E, et al. Among authors: medvedovic m. Dis Model Mech. 2024 Mar 1;17(3):dmm050669. doi: 10.1242/dmm.050669. Epub 2024 Mar 28. Dis Model Mech. 2024. PMID: 38501211 Free PMC article.
GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors.
Bhattacharya D, Barille R, Toukam DK, Gawali VS, Kallay L, Ahmed T, Brown H, Rezvanian S, Karve A, Desai PB, Medvedovic M, Wang K, Ionascu D, Harun N, Wang C, Baschnagel AM, Kritzer JA, Cook JM, Pomeranz Krummel DA, Sengupta S. Bhattacharya D, et al. Among authors: medvedovic m. bioRxiv [Preprint]. 2023 Dec 1:2023.11.29.569295. doi: 10.1101/2023.11.29.569295. bioRxiv. 2023. Update in: Cancers (Basel). 2024 Sep 15;16(18):3167. doi: 10.3390/cancers16183167 PMID: 38076805 Free PMC article. Updated. Preprint.
The Role of MAP3K1 in the Development of the Female Reproductive Tract.
Kimura E, Mongan M, Xiao B, Wang J, Carreira VS, Bolon B, Zhang X, Burns KA, Biesiada J, Medvedovic M, Puga A, Xia Y. Kimura E, et al. Among authors: medvedovic m. bioRxiv [Preprint]. 2023 Apr 21:2023.04.20.537715. doi: 10.1101/2023.04.20.537715. bioRxiv. 2023. PMID: 37131749 Free PMC article. Preprint.
174 results