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Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.
Ohtonen S, Giudice L, Jäntti H, Fazaludeen MF, Shakirzyanova A, Gómez-Budia M, Välimäki NN, Niskanen J, Korvenlaita N, Fagerlund I, Koistinaho J, Amiry-Moghaddam M, Savchenko E, Roybon L, Lehtonen Š, Korhonen P, Malm T. Ohtonen S, et al. Among authors: korhonen p. Sci Rep. 2023 Dec 13;13(1):22118. doi: 10.1038/s41598-023-49294-9. Sci Rep. 2023. PMID: 38092815 Free PMC article.
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation.
Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T. Korhonen P, et al. Brain Behav Immun. 2015 Oct;49:322-36. doi: 10.1016/j.bbi.2015.06.013. Epub 2015 Jun 22. Brain Behav Immun. 2015. PMID: 26111431
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J. Lemarchant S, et al. Among authors: korhonen p. Glia. 2016 Sep;64(9):1492-507. doi: 10.1002/glia.23017. Epub 2016 Jun 15. Glia. 2016. PMID: 27301579
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.
Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM. Huuskonen MT, et al. Among authors: korhonen p. Sci Rep. 2016 Sep 14;6:33176. doi: 10.1038/srep33176. Sci Rep. 2016. PMID: 27624652 Free PMC article.
The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.
Huuskonen MT, Tuo QZ, Loppi S, Dhungana H, Korhonen P, McInnes LE, Donnelly PS, Grubman A, Wojciechowski S, Lejavova K, Pomeshchik Y, Periviita L, Kosonen L, Giordano M, Walker FR, Liu R, Bush AI, Koistinaho J, Malm T, White AR, Lei P, Kanninen KM. Huuskonen MT, et al. Among authors: korhonen p. Neurotherapeutics. 2017 Apr;14(2):519-532. doi: 10.1007/s13311-016-0504-9. Neurotherapeutics. 2017. PMID: 28050710 Free PMC article.
HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.
Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T. Loppi S, et al. Among authors: korhonen p. Brain Behav Immun. 2018 Oct;73:670-681. doi: 10.1016/j.bbi.2018.07.021. Epub 2018 Jul 29. Brain Behav Immun. 2018. PMID: 30063972 Free PMC article.
PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.
Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T. Konttinen H, et al. Among authors: korhonen p. Glia. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19. Glia. 2019. PMID: 30453390 Free PMC article.
445 results