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Human iPSC-derived microglia carrying the LRRK2-G2019S mutation show a Parkinson's disease related transcriptional profile and function.
Ohtonen S, Giudice L, Jäntti H, Fazaludeen MF, Shakirzyanova A, Gómez-Budia M, Välimäki NN, Niskanen J, Korvenlaita N, Fagerlund I, Koistinaho J, Amiry-Moghaddam M, Savchenko E, Roybon L, Lehtonen Š, Korhonen P, Malm T. Ohtonen S, et al. Among authors: lehtonen s. Sci Rep. 2023 Dec 13;13(1):22118. doi: 10.1038/s41598-023-49294-9. Sci Rep. 2023. PMID: 38092815 Free PMC article.
Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity.
Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J. Kärkkäinen V, et al. Among authors: lehtonen s. Stem Cells. 2014 Jul;32(7):1904-16. doi: 10.1002/stem.1666. Stem Cells. 2014. PMID: 24753106
Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice With Contusion Spinal Cord Injury.
Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Åkesson E, Hovatta O, Koistinaho J. Pomeshchik Y, et al. Among authors: lehtonen s. Cell Transplant. 2015;24(9):1799-812. doi: 10.3727/096368914X684079. Epub 2014 Sep 8. Cell Transplant. 2015. PMID: 25203632 Free article.
Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation.
Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T. Korhonen P, et al. Among authors: lehtonen s. Brain Behav Immun. 2015 Oct;49:322-36. doi: 10.1016/j.bbi.2015.06.013. Epub 2015 Jun 22. Brain Behav Immun. 2015. PMID: 26111431
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Liddell JR, Lehtonen S, Duncan C, Keksa-Goldsteine V, Levonen AL, Goldsteins G, Malm T, White AR, Koistinaho J, Kanninen KM. Liddell JR, et al. Among authors: lehtonen s. J Neuroinflammation. 2016 Feb 26;13:49. doi: 10.1186/s12974-016-0515-9. J Neuroinflammation. 2016. PMID: 26920699 Free PMC article.
234 results