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SHP2 inhibitors maintain TGFβ signalling through SMURF2 inhibition.
Lai X, Lui SKL, Lam HY, Adachi Y, Sim WJ, Vasilevski N, Armstrong NJ, Bridgeman SC, Main NM, Tan TZ, Tirnitz-Parker JEE, Thiery JP, Ebi H, Kumar AP, Eichhorn PJA. Lai X, et al. Among authors: bridgeman sc. NPJ Precis Oncol. 2023 Dec 15;7(1):136. doi: 10.1038/s41698-023-00486-6. NPJ Precis Oncol. 2023. PMID: 38102334 Free PMC article.
High-fat diet induced alterations in plasma membrane cholesterol content impairs insulin receptor binding and signalling in mouse liver but is ameliorated by atorvastatin.
Sabapathy T, Helmerhorst E, Ellison G, Bridgeman SC, Mamotte CD. Sabapathy T, et al. Among authors: bridgeman sc. Biochim Biophys Acta Mol Basis Dis. 2022 Jun 1;1868(6):166372. doi: 10.1016/j.bbadis.2022.166372. Epub 2022 Mar 4. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35248691 Free article.