Goncharov T - Search Results

1

Inhibition of RIP1 improves immune reconstitution and reduces GVHD mortality while preserving graft-versus-leukemia effects.

Prado-Acosta M, Jeong S, Utrero-Rico A, Goncharov T, Webster JD, Holler E, Morales G, Dellepiane S, Levine JE, Rothenberg ME, Vucic D, Ferrara JLM. Prado-Acosta M, et al. Among authors: goncharov t. Sci Transl Med. 2023 Dec 20;15(727):eadf8366. doi: 10.1126/scitranslmed.adf8366. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117900 Free PMC article.

2

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.

Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D. Varfolomeev E, et al. Among authors: goncharov t. J Biol Chem. 2008 Sep 5;283(36):24295-9. doi: 10.1074/jbc.C800128200. Epub 2008 Jul 11. J Biol Chem. 2008. PMID: 18621737 Free PMC article.

3

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D. Blankenship JW, et al. Among authors: goncharov t. Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885. Biochem J. 2009. PMID: 18939944

4

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Cohen F, et al. Among authors: goncharov t. J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c. J Med Chem. 2009. PMID: 19228017

5

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D. Dynek JN, et al. Among authors: goncharov t. EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26. EMBO J. 2010. PMID: 21113135 Free PMC article.

6

Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Varfolomeev E, Goncharov T, Maecker H, Zobel K, Kömüves LG, Deshayes K, Vucic D. Varfolomeev E, et al. Among authors: goncharov t. Sci Signal. 2012 Mar 20;5(216):ra22. doi: 10.1126/scisignal.2001878. Sci Signal. 2012. PMID: 22434933

7

OTUB1 modulates c-IAP1 stability to regulate signalling pathways.

Goncharov T, Niessen K, de Almagro MC, Izrael-Tomasevic A, Fedorova AV, Varfolomeev E, Arnott D, Deshayes K, Kirkpatrick DS, Vucic D. Goncharov T, et al. EMBO J. 2013 Apr 17;32(8):1103-14. doi: 10.1038/emboj.2013.62. Epub 2013 Mar 22. EMBO J. 2013. PMID: 23524849 Free PMC article.

8

Ubiquitination profiling identifies sensitivity factors for IAP antagonist treatment.

Varfolomeev E, Izrael-Tomasevic A, Yu K, Bustos D, Goncharov T, Belmont LD, Masselot A, Bakalarski CE, Kirkpatrick DS, Vucic D. Varfolomeev E, et al. Among authors: goncharov t. Biochem J. 2015 Feb 15;466(1):45-54. doi: 10.1042/BJ20141195. Biochem J. 2015. PMID: 25423073

9

Roles of c-IAP proteins in TNF receptor family activation of NF-κB signaling.

Varfolomeev E, Goncharov T, Vucic D. Varfolomeev E, et al. Among authors: goncharov t. Methods Mol Biol. 2015;1280:269-82. doi: 10.1007/978-1-4939-2422-6_15. Methods Mol Biol. 2015. PMID: 25736754

10

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination.

de Almagro MC, Goncharov T, Newton K, Vucic D. de Almagro MC, et al. Among authors: goncharov t. Cell Death Dis. 2015 Jun 25;6(6):e1800. doi: 10.1038/cddis.2015.158. Cell Death Dis. 2015. PMID: 26111062 Free PMC article.

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