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Exhaustion, rather than lack of infiltration and persistence, of CAR-T cells hampers the efficacy of CAR-T therapy in an orthotopic PDAC xenograft model.
Takeuchi Y, Wang Y, Sasaki K, Sato O, Tsuchikawa T, Wang L, Amaishi Y, Okamoto S, Mineno J, Hirokawa Y, Hatanaka KC, Hatanaka Y, Kato T, Shiku H, Hirano S. Takeuchi Y, et al. Among authors: wang l, wang y. Biomed Pharmacother. 2024 Jan;170:116052. doi: 10.1016/j.biopha.2023.116052. Epub 2023 Dec 22. Biomed Pharmacother. 2024. PMID: 38141280 Free article.
Tumor Growth Suppression of Pancreatic Cancer Orthotopic Xenograft Model by CEA-Targeting CAR-T Cells.
Sato O, Tsuchikawa T, Kato T, Amaishi Y, Okamoto S, Mineno J, Takeuchi Y, Sasaki K, Nakamura T, Umemoto K, Suzuki T, Wang L, Wang Y, Hatanaka KC, Mitsuhashi T, Hatanaka Y, Shiku H, Hirano S. Sato O, et al. Among authors: wang l, wang y. Cancers (Basel). 2023 Jan 18;15(3):601. doi: 10.3390/cancers15030601. Cancers (Basel). 2023. PMID: 36765558 Free PMC article.
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