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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris JC, Don AS, Garfield A, Zarini S, Zemski Berry KA, Ryan AP, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. Among authors: brozinick jt. Elife. 2023 Dec 27;12:RP87340. doi: 10.7554/eLife.87340. Elife. 2023. PMID: 38149844 Free PMC article.
Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance.
Fazakerley DJ, van Gerwen J, Cooke KC, Duan X, Needham EJ, Díaz-Vegas A, Madsen S, Norris DM, Shun-Shion AS, Krycer JR, Burchfield JG, Yang P, Wade MR, Brozinick JT, James DE, Humphrey SJ. Fazakerley DJ, et al. Among authors: brozinick jt. Nat Commun. 2023 Feb 18;14(1):923. doi: 10.1038/s41467-023-36549-2. Nat Commun. 2023. PMID: 36808134 Free PMC article.
Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris J, Don A, Garfield A, Zarini S, Zemski Berry KA, Ryan A, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. Among authors: brozinick jt. bioRxiv [Preprint]. 2023 Sep 19:2023.03.10.532020. doi: 10.1101/2023.03.10.532020. bioRxiv. 2023. Update in: Elife. 2023 Dec 27;12:RP87340. doi: 10.7554/eLife.87340 PMID: 36945619 Free PMC article. Updated. Preprint.
An early, reversible cholesterolgenic etiology of diet-induced insulin resistance.
Covert JD, Grice BA, Thornburg MG, Kaur M, Ryan AP, Tackett L, Bhamidipati T, Stull ND, Kim T, Habegger KM, McClain DA, Brozinick JT, Elmendorf JS. Covert JD, et al. Among authors: brozinick jt. Mol Metab. 2023 Jun;72:101715. doi: 10.1016/j.molmet.2023.101715. Epub 2023 Apr 3. Mol Metab. 2023. PMID: 37019209 Free PMC article.
Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.
Samms RJ, Zhang G, He W, Ilkayeva O, Droz BA, Bauer SM, Stutsman C, Pirro V, Collins KA, Furber EC, Coskun T, Sloop KW, Brozinick JT, Newgard CB. Samms RJ, et al. Among authors: brozinick jt. Mol Metab. 2022 Oct;64:101550. doi: 10.1016/j.molmet.2022.101550. Epub 2022 Jul 31. Mol Metab. 2022. PMID: 35921984 Free PMC article.
Modified UCN2 peptide treatment improves skeletal muscle mass and function in mouse models of obesity-induced insulin resistance.
Borg ML, Massart J, De Castro Barbosa T, Archilla-Ortega A, Smith JAB, Lanner JT, Alsina-Fernandez J, Yaden B, Culver AE, Karlsson HKR, Brozinick JT, Zierath JR. Borg ML, et al. Among authors: brozinick jt. J Cachexia Sarcopenia Muscle. 2021 Oct;12(5):1232-1248. doi: 10.1002/jcsm.12746. Epub 2021 Aug 2. J Cachexia Sarcopenia Muscle. 2021. PMID: 34342159 Free PMC article.
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.
Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Walejko JM, et al. Among authors: brozinick jt. Nat Commun. 2021 Mar 15;12(1):1680. doi: 10.1038/s41467-021-21962-2. Nat Commun. 2021. PMID: 33723250 Free PMC article.
75 results