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Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris JC, Don AS, Garfield A, Zarini S, Zemski Berry KA, Ryan AP, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. Among authors: lim xy. Elife. 2023 Dec 27;12:RP87340. doi: 10.7554/eLife.87340. Elife. 2023. PMID: 38149844 Free PMC article.
Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle.
Diaz-Vegas A, Madsen S, Cooke KC, Carroll L, Khor JXY, Turner N, Lim XY, Astore MA, Morris J, Don A, Garfield A, Zarini S, Zemski Berry KA, Ryan A, Bergman BC, Brozinick JT, James DE, Burchfield JG. Diaz-Vegas A, et al. Among authors: lim xy. bioRxiv [Preprint]. 2023 Sep 19:2023.03.10.532020. doi: 10.1101/2023.03.10.532020. bioRxiv. 2023. Update in: Elife. 2023 Dec 27;12:RP87340. doi: 10.7554/eLife.87340 PMID: 36945619 Free PMC article. Updated. Preprint.
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.
Turner N, Lim XY, Toop HD, Osborne B, Brandon AE, Taylor EN, Fiveash CE, Govindaraju H, Teo JD, McEwen HP, Couttas TA, Butler SM, Das A, Kowalski GM, Bruce CR, Hoehn KL, Fath T, Schmitz-Peiffer C, Cooney GJ, Montgomery MK, Morris JC, Don AS. Turner N, et al. Among authors: lim xy. Nat Commun. 2018 Aug 21;9(1):3165. doi: 10.1038/s41467-018-05613-7. Nat Commun. 2018. PMID: 30131496 Free PMC article.
Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.
Montgomery MK, Brown SH, Lim XY, Fiveash CE, Osborne B, Bentley NL, Braude JP, Mitchell TW, Coster AC, Don AS, Cooney GJ, Schmitz-Peiffer C, Turner N. Montgomery MK, et al. Among authors: lim xy. Biochim Biophys Acta. 2016 Nov;1861(11):1828-1839. doi: 10.1016/j.bbalip.2016.08.016. Epub 2016 Aug 31. Biochim Biophys Acta. 2016. PMID: 27591968
66 results