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Towards in vitro models for reducing or replacing the use of animals in drug testing.
Stresser DM, Kopec AK, Hewitt P, Hardwick RN, Van Vleet TR, Mahalingaiah PKS, O'Connell D, Jenkins GJ, David R, Graham J, Lee D, Ekert J, Fullerton A, Villenave R, Bajaj P, Gosset JR, Ralston SL, Guha M, Amador-Arjona A, Khan K, Agarwal S, Hasselgren C, Wang X, Adams K, Kaushik G, Raczynski A, Homan KA. Stresser DM, et al. Among authors: gosset jr. Nat Biomed Eng. 2024 Aug;8(8):930-935. doi: 10.1038/s41551-023-01154-7. Nat Biomed Eng. 2024. PMID: 38151640 No abstract available.
The Current Status and Use of Microphysiological Systems by the Pharmaceutical Industry: The International Consortium for Innovation and Quality Microphysiological Systems Affiliate Survey and Commentary.
Baker TK, Van Vleet TR, Mahalingaiah PK, Grandhi TSP, Evers R, Ekert J, Gosset JR, Chacko SA, Kopec AK. Baker TK, et al. Among authors: gosset jr. Drug Metab Dispos. 2024 Feb 14;52(3):198-209. doi: 10.1124/dmd.123.001510. Drug Metab Dispos. 2024. PMID: 38123948
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life.
Filipski KJ, Edmonds DJ, Garnsey MR, Smaltz DJ, Coffman K, Futatsugi K, Lee J, O'Neil SV, Wright A, Nason D, Gosset JR, Orozco CC, Blackler D, Fakhoury G, Gutierrez JA, Perez S, Ross T, Stock I, Tesz G, Dullea R. Filipski KJ, et al. Among authors: gosset jr. ACS Med Chem Lett. 2023 Oct 2;14(10):1427-1433. doi: 10.1021/acsmedchemlett.3c00330. eCollection 2023 Oct 12. ACS Med Chem Lett. 2023. PMID: 37849537 Free PMC article.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Tomlinson L, Ramsden D, Leite SB, Beken S, Bonzo JA, Brown P, Candarlioglu PL, Chan TS, Chen E, Choi CK, David R, Delrue N, Devine PJ, Ford K, Garcia MI, Gosset JR, Hewitt P, Homan K, Irrechukwu O, Kopec AK, Liras JL, Mandlekar S, Raczynski A, Sadrieh N, Sakatis MZ, Siegel J, Sung K, Sunyovszki I, Van Vleet TR, Ekert JE, Hardwick RN. Tomlinson L, et al. Among authors: gosset jr. Adv Biol (Weinh). 2024 Aug;8(8):e2300131. doi: 10.1002/adbi.202300131. Epub 2023 Oct 9. Adv Biol (Weinh). 2024. PMID: 37814378
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Futatsugi K, Cabral S, Kung DW, Huard K, Lee E, Boehm M, Bauman J, Clark RW, Coffey SB, Crowley C, Dechert-Schmitt AM, Dowling MS, Dullea R, Gosset JR, Kalgutkar AS, Kou K, Li Q, Lian Y, Loria PM, Londregan AT, Niosi M, Orozco C, Pettersen JC, Pfefferkorn JA, Polivkova J, Ross TT, Sharma R, Stock IA, Tesz G, Wisniewska H, Goodwin B, Price DA. Futatsugi K, et al. Among authors: gosset jr. J Med Chem. 2022 Nov 24;65(22):15000-15013. doi: 10.1021/acs.jmedchem.2c01200. Epub 2022 Nov 2. J Med Chem. 2022. PMID: 36322383
Quantitative prediction of breast cancer resistant protein mediated drug-drug interactions using physiologically-based pharmacokinetic modeling.
Costales C, Lin J, Kimoto E, Yamazaki S, Gosset JR, Rodrigues AD, Lazzaro S, West MA, West M, Varma MVS. Costales C, et al. Among authors: gosset jr. CPT Pharmacometrics Syst Pharmacol. 2021 Sep;10(9):1018-1031. doi: 10.1002/psp4.12672. Epub 2021 Jul 20. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34164937 Free PMC article.
Correction: A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions.
Tan K , Coppeta J , Azizgolshani H , Isenberg BC , Keegan PM , Cain BP , Patterson AJ , Kim ES , Kratchman LB , Rogers M , Haroutunian N , Newlin V , Golmon S , Tandon V , Lu M , Gosset JR , Vedula EM , Charest JL , Bale SS . Tan K , et al. Among authors: gosset jr. Lab Chip. 2020 Oct 7;20(19):3653. doi: 10.1039/d0lc90069a. Epub 2020 Aug 5. Lab Chip. 2020. PMID: 32756648
92 results