Shevlin M - Search Results

1

A General Strategy for N-(Hetero)arylpiperidine Synthesis Using Zincke Imine Intermediates.

Selingo JD, Greenwood JW, Andrews MK, Patel C, Neel AJ, Pio B, Shevlin M, Phillips EM, Maddess ML, McNally A. Selingo JD, et al. Among authors: shevlin m. J Am Chem Soc. 2024 Jan 10;146(1):936-945. doi: 10.1021/jacs.3c11504. Epub 2023 Dec 28. J Am Chem Soc. 2024. PMID: 38153812

2

Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine.

Molinaro C, Phillips EM, Xiang B, Milczek E, Shevlin M, Balsells J, Ceglia S, Chen J, Chen L, Chen Q, Fei Z, Hoerrner S, Qi J, de Lera Ruiz M, Tan L, Wan B, Yin J. Molinaro C, et al. Among authors: shevlin m. J Org Chem. 2019 Jun 21;84(12):8006-8018. doi: 10.1021/acs.joc.9b00569. Epub 2019 Jun 5. J Org Chem. 2019. PMID: 31124362

3

Accessing Diverse Azole Carboxylic Acid Building Blocks via Mild C-H Carboxylation: Parallel, One-Pot Amide Couplings and Machine-Learning-Guided Substrate Scope Design.

Felten S, He CQ, Weisel M, Shevlin M, Emmert MH. Felten S, et al. Among authors: shevlin m. J Am Chem Soc. 2022 Dec 21;144(50):23115-23126. doi: 10.1021/jacs.2c10557. Epub 2022 Dec 9. J Am Chem Soc. 2022. PMID: 36490321

4

Cobalt-Catalyzed Enantioselective Hydrogenation of Minimally Functionalized Alkenes: Isotopic Labeling Provides Insight into the Origin of Stereoselectivity and Alkene Insertion Preferences.

Friedfeld MR, Shevlin M, Margulieux GW, Campeau LC, Chirik PJ. Friedfeld MR, et al. Among authors: shevlin m. J Am Chem Soc. 2016 Mar 16;138(10):3314-24. doi: 10.1021/jacs.5b10148. Epub 2016 Mar 1. J Am Chem Soc. 2016. PMID: 26854359

5

Catalytic, asymmetric, and stereodivergent synthesis of non-symmetric β,β-diaryl-α-amino acids.

Molinaro C, Scott JP, Shevlin M, Wise C, Ménard A, Gibb A, Junker EM, Lieberman D. Molinaro C, et al. Among authors: shevlin m. J Am Chem Soc. 2015 Jan 21;137(2):999-1006. doi: 10.1021/ja511872a. Epub 2015 Jan 7. J Am Chem Soc. 2015. PMID: 25523503

6

Total Synthesis of Darobactin A.

Nesic M, Ryffel DB, Maturano J, Shevlin M, Pollack SR, Gauthier DR Jr, Trigo-Mouriño P, Zhang LK, Schultz DM, McCabe Dunn JM, Campeau LC, Patel NR, Petrone DA, Sarlah D. Nesic M, et al. Among authors: shevlin m. J Am Chem Soc. 2022 Aug 10;144(31):14026-14030. doi: 10.1021/jacs.2c05891. Epub 2022 Jul 28. J Am Chem Soc. 2022. PMID: 35900216

7

Nickel-Catalyzed Asymmetric Alkene Hydrogenation of α,β-Unsaturated Esters: High-Throughput Experimentation-Enabled Reaction Discovery, Optimization, and Mechanistic Elucidation.

Shevlin M, Friedfeld MR, Sheng H, Pierson NA, Hoyt JM, Campeau LC, Chirik PJ. Shevlin M, et al. J Am Chem Soc. 2016 Mar 16;138(10):3562-9. doi: 10.1021/jacs.6b00519. Epub 2016 Mar 2. J Am Chem Soc. 2016. PMID: 26890979

8

Cobalt-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids by Homolytic H₂ Cleavage.

Zhong H, Shevlin M, Chirik PJ. Zhong H, et al. Among authors: shevlin m. J Am Chem Soc. 2020 Mar 18;142(11):5272-5281. doi: 10.1021/jacs.9b13876. Epub 2020 Mar 3. J Am Chem Soc. 2020. PMID: 32064867

9

Mechanistic Investigations of the Asymmetric Hydrogenation of Enamides with Neutral Bis(phosphine) Cobalt Precatalysts.

Mendelsohn LN, Pavlovic L, Zhong H, Friedfeld MR, Shevlin M, Hopmann KH, Chirik PJ. Mendelsohn LN, et al. Among authors: shevlin m. J Am Chem Soc. 2022 Aug 31;144(34):15764-15778. doi: 10.1021/jacs.2c06454. Epub 2022 Aug 11. J Am Chem Soc. 2022. PMID: 35951601

10

The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis.

Krska SW, DiRocco DA, Dreher SD, Shevlin M. Krska SW, et al. Among authors: shevlin m. Acc Chem Res. 2017 Dec 19;50(12):2976-2985. doi: 10.1021/acs.accounts.7b00428. Epub 2017 Nov 27. Acc Chem Res. 2017. PMID: 29172435

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