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Optimization of the Central α-Amino Acid in Cystobactamids to the Broad-Spectrum, Resistance-Breaking Antibiotic CN-CC-861.
Kohnhäuser D, Seedorf T, Cirnski K, Heimann D, Coetzee J, Sordello S, Richter J, Stappert M, Sabuco JF, Corbett D, Bacqué E, Rox K, Herrmann J, Vassort A, Müller R, Kirschning A, Brönstrup M. Kohnhäuser D, et al. Among authors: sabuco jf. J Med Chem. 2024 Oct 10;67(19):17162-17190. doi: 10.1021/acs.jmedchem.4c00927. Epub 2024 Sep 20. J Med Chem. 2024. PMID: 39303218 Free PMC article.
Studies of antibacterial activity (in vitro and in vivo) and mode of action for des-acyl tridecaptins (DATs).
Couturier C, Ronzon Q, Lattanzi G, Lingard I, Coyne S, Cazals V, Dubarry N, Yvon S, Leroi-Geissler C, Gracia OR, Teague J, Sordello S, Corbett D, Bauch C, Monlong C, Payne L, Taillier T, Fuchs H, Broenstrup M, Harrison PH, Moynié L, Lakshminarayanan A, Gianga TM, Hussain R, Naismith JH, Mourez M, Bacqué E, Björkling F, Sabuco JF, Franzyk H. Couturier C, et al. Among authors: sabuco jf. Eur J Med Chem. 2024 Feb 5;265:116097. doi: 10.1016/j.ejmech.2023.116097. Epub 2023 Dec 23. Eur J Med Chem. 2024. PMID: 38157595