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Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Ledo JH, Liebmann T, Zhang R, Chang JC, Azevedo EP, Wong E, Silva HM, Troyanskaya OG, Bustos V, Greengard P. Ledo JH, et al. Mol Psychiatry. 2021 Oct;26(10):5620-5635. doi: 10.1038/s41380-020-0856-8. Epub 2020 Aug 13. Mol Psychiatry. 2021. PMID: 32792660 Free PMC article.
Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.
Melo HM, Seixas da Silva GDS, Sant'Ana MR, Teixeira CVL, Clarke JR, Miya Coreixas VS, de Melo BC, Fortuna JTS, Forny-Germano L, Ledo JH, Oliveira MS, Figueiredo CP, Pardossi-Piquard R, Checler F, Delgado-García JM, Gruart A, Velloso LA, Balthazar MLF, Cintra DE, Ferreira ST, De Felice FG. Melo HM, et al. Among authors: ledo jh. Cell Rep. 2020 Feb 18;30(7):2180-2194.e8. doi: 10.1016/j.celrep.2020.01.072. Cell Rep. 2020. PMID: 32075735 Free article.
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.
Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST. Brito-Moreira J, et al. Among authors: ledo jh. J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10. J Biol Chem. 2017. PMID: 28283575 Free PMC article.
Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.
Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST. Ledo JH, et al. J Neurosci. 2016 Nov 30;36(48):12106-12116. doi: 10.1523/JNEUROSCI.1269-16.2016. J Neurosci. 2016. PMID: 27903721 Free PMC article.
16 results