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Page 1
Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer.
Sánchez-Castillo A, Heylen E, Hounjet J, Savelkouls KG, Lieuwes NG, Biemans R, Dubois LJ, Reynders K, Rouschop KM, Vaes RDW, De Keersmaecker K, Lambrecht M, Hendriks LEL, De Ruysscher DKM, Vooijs M, Kampen KR. Sánchez-Castillo A, et al. Among authors: savelkouls kg. Br J Cancer. 2024 Mar;130(4):568-584. doi: 10.1038/s41416-023-02553-y. Epub 2023 Dec 30. Br J Cancer. 2024. PMID: 38160212 Free PMC article.
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG. Rouschop KM, et al. J Clin Invest. 2010 Jan;120(1):127-41. doi: 10.1172/JCI40027. Epub 2009 Dec 14. J Clin Invest. 2010. PMID: 20038797 Free PMC article.
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia.
Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, Wouters BG, Rouschop KM. Schaaf MB, et al. Among authors: savelkouls kg. Radiother Oncol. 2013 Sep;108(3):529-34. doi: 10.1016/j.radonc.2013.06.015. Epub 2013 Jul 9. Radiother Oncol. 2013. PMID: 23849170
Canonical autophagy does not contribute to cellular radioresistance.
Schaaf MB, Jutten B, Keulers TG, Savelkouls KG, Peeters HJ, van den Beucken T, van Schooten FJ, Godschalk RW, Vooijs M, Rouschop KM. Schaaf MB, et al. Among authors: savelkouls kg. Radiother Oncol. 2015 Mar;114(3):406-12. doi: 10.1016/j.radonc.2015.02.019. Epub 2015 Mar 13. Radiother Oncol. 2015. PMID: 25779723
GABARAPL1 is required for increased EGFR membrane expression during hypoxia.
Keulers TG, Schaaf MB, Peeters HJ, Savelkouls KG, Vooijs MA, Bussink J, Jutten B, Rouschop KM. Keulers TG, et al. Among authors: savelkouls kg. Radiother Oncol. 2015 Sep;116(3):417-22. doi: 10.1016/j.radonc.2015.06.023. Epub 2015 Jul 8. Radiother Oncol. 2015. PMID: 26164772
22 results