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Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques.
Lee BC, Gin A, Wu C, Singh K, Grice M, Mortlock R, Abraham D, Fan X, Zhou Y, AlJanahi A, Choi U, de Ravin SS, Shin T, Hong S, Dunbar CE. Lee BC, et al. Among authors: fan x. bioRxiv [Preprint]. 2023 Dec 13:2023.12.13.571396. doi: 10.1101/2023.12.13.571396. bioRxiv. 2023. Update in: Cell Stem Cell. 2024 Apr 4;31(4):455-466.e4. doi: 10.1016/j.stem.2024.02.010 PMID: 38168153 Free PMC article. Updated. Preprint.
The impact of aging on primate hematopoiesis as interrogated by clonal tracking.
Yu KR, Espinoza DA, Wu C, Truitt L, Shin TH, Chen S, Fan X, Yabe IM, Panch S, Hong SG, Koelle S, Lu R, Bonifacino A, Krouse A, Metzger M, Donahue RE, Dunbar CE. Yu KR, et al. Among authors: fan x. Blood. 2018 Mar 15;131(11):1195-1205. doi: 10.1182/blood-2017-08-802033. Epub 2018 Jan 2. Blood. 2018. PMID: 29295845 Free PMC article.
Aberrant Clonal Hematopoiesis following Lentiviral Vector Transduction of HSPCs in a Rhesus Macaque.
Espinoza DA, Fan X, Yang D, Cordes SF, Truitt LL, Calvo KR, Yabe IM, Demirci S, Hope KJ, Hong SG, Krouse A, Metzger M, Bonifacino A, Lu R, Uchida N, Tisdale JF, Wu X, DeRavin SS, Malech HL, Donahue RE, Wu C, Dunbar CE. Espinoza DA, et al. Among authors: fan x. Mol Ther. 2019 Jun 5;27(6):1074-1086. doi: 10.1016/j.ymthe.2019.04.003. Epub 2019 Apr 9. Mol Ther. 2019. PMID: 31023523 Free PMC article.
Clonal tracking of erythropoiesis in rhesus macaques.
Fan X, Wu C, Truitt LL, Espinoza DA, Sellers S, Bonifacino A, Zhou Y, Cordes SF, Krouse A, Metzger M, Donahue RE, Lu R, Dunbar CE. Fan X, et al. Haematologica. 2020 Jul;105(7):1813-1824. doi: 10.3324/haematol.2019.231811. Epub 2019 Oct 3. Haematologica. 2020. PMID: 31582555 Free PMC article.
Prediction and validation of hematopoietic stem and progenitor cell off-target editing in transplanted rhesus macaques.
AlJanahi AA, Lazzarotto CR, Chen S, Shin TH, Cordes S, Fan X, Jabara I, Zhou Y, Young DJ, Lee BC, Yu KR, Li Y, Toms B, Tunc I, Hong SG, Truitt LL, Klermund J, Andrieux G, Kim MY, Cathomen T, Gill S, Tsai SQ, Dunbar CE. AlJanahi AA, et al. Among authors: fan x. Mol Ther. 2022 Jan 5;30(1):209-222. doi: 10.1016/j.ymthe.2021.06.016. Epub 2021 Jun 24. Mol Ther. 2022. PMID: 34174439 Free PMC article.
A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions.
Shin TH, Zhou Y, Chen S, Cordes S, Grice MZ, Fan X, Lee BC, Aljanahi AA, Hong SG, Vaughan KL, Mattison JA, Kohama SG, Fabre MA, Uchida N, Demirci S, Corat MAF, Métais JY, Calvo KR, Buscarlet M, Natanson H, McGraw KL, List AF, Busque L, Tisdale JF, Vassiliou GS, Yu KR, Dunbar CE. Shin TH, et al. Among authors: fan x. Blood. 2022 Oct 20;140(16):1774-1789. doi: 10.1182/blood.2021014875. Blood. 2022. PMID: 35714307 Free PMC article.
Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques.
Abraham DM, Lozano RJ, Guitart X, Liang JA, Mortlock RD, Espinoza DA, Fan X, Krouse A, Bonifacino A, Hong SG, Singh K, Tisdale JF, Wu C, Dunbar CE. Abraham DM, et al. Among authors: fan x. Mol Ther Methods Clin Dev. 2022 Dec 6;28:62-75. doi: 10.1016/j.omtm.2022.12.001. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2022. PMID: 36620072 Free PMC article.
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