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Page 1
3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes.
Scudese E, Vue Z, Katti P, Marshall AG, Demirci M, Vang L, López EG, Neikirk K, Shao B, Le H, Stephens D, Hall DD, Rostami R, Rodman T, Kabugi K, Harris C, Shao J, Mungai M, AshShareef ST, Hicsasmaz I, Manus S, Wanjalla C, Whiteside A, Dasari R, Williams C, Damo SM, Gaddy JA, Glancy B, Dantas EHM, Kinder A, Kadam A, Tomar D, Scartoni F, Baffi M, McReynolds MR, Phillips MA, Cooper A, Murray SA, Quintana AM, Exil V, Kirabo A, Mobley BC, Hinton A. Scudese E, et al. Among authors: mcreynolds mr. bioRxiv [Preprint]. 2024 Jun 8:2023.11.13.566502. doi: 10.1101/2023.11.13.566502. bioRxiv. 2024. PMID: 38168206 Free PMC article. Preprint.
Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts.
Vue Z, Ajayi PT, Neikirk K, Murphy AC, Prasad P, Jenkins BC, Vang L, Garza-Lopez E, Mungai M, Marshall AG, Beasley HK, Killion M, Parker R, Anukodem J, Lavine K, Ajijola O, Mobley BC, Dai DF, Exil V, Kirabo A, Su YR, Tomasek K, Zhang X, Wanjalla C, Hubert DL, Phillips MA, Shao JQ, McReynolds MR, Glancy B, Hinton A Jr. Vue Z, et al. Among authors: mcreynolds mr. bioRxiv [Preprint]. 2023 Dec 14:2023.11.28.569095. doi: 10.1101/2023.11.28.569095. bioRxiv. 2023. PMID: 38076993 Free PMC article. Preprint.
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Among authors: mcreynolds mr. bioRxiv [Preprint]. 2024 Jun 28:2024.06.23.598940. doi: 10.1101/2024.06.23.598940. bioRxiv. 2024. Update in: Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131 PMID: 38979192 Free PMC article. Updated. Preprint.
Human genetics identify convergent signals in mitochondrial LACTB-mediated lipid metabolism in cardiovascular-kidney-metabolic syndrome.
Li S, Liu H, Hu H, Ha E, Prasad P, Jenkins BC, Das US, Mukherjee S, Shishikura K, Hu R, Rader DJ, Pei L, Baur JA, Matthews ML, FitzGerald GA, McReynolds MR, Susztak K. Li S, et al. Among authors: mcreynolds mr. Cell Metab. 2025 Jan 7;37(1):154-168.e7. doi: 10.1016/j.cmet.2024.10.007. Epub 2024 Nov 18. Cell Metab. 2025. PMID: 39561766
Systemic inhibition of de novo purine biosynthesis prevents weight gain and improves metabolic health by increasing thermogenesis and decreasing food intake.
Myers JW, Park WY, Eddie AM, Shinde AB, Prasad P, Murphy AC, Leonard MZ, Pinette JA, Rampy JJ, Montufar C, Shaikh Z, Hickman TT, Reynolds GN, Winn NC, Lantier L, Peck SH, Coate KC, Stein RW, Carrasco N, Calipari ES, McReynolds MR, Zaganjor E. Myers JW, et al. Among authors: mcreynolds mr. bioRxiv [Preprint]. 2024 Nov 1:2024.10.28.620705. doi: 10.1101/2024.10.28.620705. bioRxiv. 2024. PMID: 39553975 Free PMC article. Preprint.
HIV persists in late coronary atheroma and is associated with increased local inflammation and disease progression.
Obare LM, Bailin SS, Zhang X, Nthenge K, Priest S, Liu Q, Stolze LK, Sheng Q, Gangula R, Behrens M, Jenkins B, Prasad P, Neikirk K, Prakash P, Hogan M, Zhang L, Beasley HK, Shao J, Miller-Fleming TW, Actkins KV, Phillips MA, Hubert D, Malone J, Labeeb C, Gelbard A, Chaillon A, Mashayekhi M, Gabriel CL, Temu T, Olson L, Jones A, Beeri K, Baker P, Kawai K, Ghosh SKB, Guo L, Virmani R, Finn A, Shah P, Yang TS, Bick AG, Kirabo A, Su YR, Phillips EJ, Mallal S, Dash C, Koethe JR, Gianella S, McReynolds MR, Absi T, Hinton A, Wanjalla CN. Obare LM, et al. Among authors: mcreynolds mr. Res Sq [Preprint]. 2024 Oct 18:rs.3.rs-5125826. doi: 10.21203/rs.3.rs-5125826/v1. Res Sq. 2024. PMID: 39483879 Free PMC article. Preprint.
A metabolic constraint in the kynurenine pathway drives mucosal inflammation in IBD.
Welz L, Harris DM, Kim NM, Alsaadi AI, Wu Q, Oumari M, Taubenheim J, Volk V, Credido G, Koncina E, Mukherjee PK, Tran F, Sievers LK, Pavlidis P, Powell N, Rieder F, Letellier E, Waschina S, Kaleta C, Feuerhake F, Verstockt B, McReynolds MR, Rosenstiel P, Schreiber S, Aden K. Welz L, et al. Among authors: mcreynolds mr. medRxiv [Preprint]. 2024 Aug 8:2024.08.08.24311598. doi: 10.1101/2024.08.08.24311598. medRxiv. 2024. PMID: 39211892 Free PMC article. Preprint.
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies.
Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. Minhas PS, et al. Among authors: mcreynolds mr. Science. 2024 Aug 23;385(6711):eabm6131. doi: 10.1126/science.abm6131. Epub 2024 Aug 23. Science. 2024. PMID: 39172838
Quantitative assessment of morphological changes in lipid droplets and lipid-mito interactions with aging in brown adipose.
Crabtree A, Neikirk K, Pinette JA, Whiteside A, Shao B, Bedenbaugh J, Vue Z, Vang L, Le H, Demirci M, Ahmad T, Owens TC, Oliver A, Zeleke F, Beasley HK, Lopez EG, Scudese E, Rodman T, Kabugi K, Koh A, Navarro S, Lam J, Kirk B, Mungai M, Sweetwyne M, Koh HJ, Zaganjor E, Damo SM, Gaddy JA, Kirabo A, Murray SA, Cooper A, Williams C, McReynolds MR, Marshall AG, Hinton A Jr. Crabtree A, et al. Among authors: mcreynolds mr. J Cell Physiol. 2024 Sep;239(9):e31340. doi: 10.1002/jcp.31340. Epub 2024 Aug 13. J Cell Physiol. 2024. PMID: 39138923
Selection for early reproduction leads to accelerated aging and extensive metabolic remodeling in Drosophila melanogaster.
Hubert DL, Arnold KR, Greenspan ZG, Pupo A, Robinson RD, Chavarin VV, Barter TB, Djukovic D, Raftery D, Vue Z, Hinton A, McReynolds MR, Harrison BR, Phillips MA. Hubert DL, et al. Among authors: mcreynolds mr. bioRxiv [Preprint]. 2024 Nov 27:2024.06.28.601037. doi: 10.1101/2024.06.28.601037. bioRxiv. 2024. PMID: 39005259 Free PMC article. Preprint.
66 results