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Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OM, Wilkinson M, Mackinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE. Aubrey LD, et al. Among authors: peters om. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2309700120. doi: 10.1073/pnas.2309700120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170745 Free PMC article.
Gamma-synuclein pathology in amyotrophic lateral sclerosis.
Peters OM, Shelkovnikova T, Highley JR, Cooper-Knock J, Hortobágyi T, Troakes C, Ninkina N, Buchman VL. Peters OM, et al. Ann Clin Transl Neurol. 2015 Jan;2(1):29-37. doi: 10.1002/acn3.143. Epub 2014 Dec 12. Ann Clin Transl Neurol. 2015. PMID: 25642432 Free PMC article.
Dimebon slows progression of proteinopathy in γ-synuclein transgenic mice.
Bachurin SO, Shelkovnikova TA, Ustyugov AA, Peters O, Khritankova I, Afanasieva MA, Tarasova TV, Alentov II, Buchman VL, Ninkina NN. Bachurin SO, et al. Neurotox Res. 2012 Jul;22(1):33-42. doi: 10.1007/s12640-011-9299-y. Epub 2011 Dec 17. Neurotox Res. 2012. PMID: 22179976 Free PMC article.
Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.
Shelkovnikova TA, Peters OM, Deykin AV, Connor-Robson N, Robinson H, Ustyugov AA, Bachurin SO, Ermolkevich TG, Goldman IL, Sadchikova ER, Kovrazhkina EA, Skvortsova VI, Ling SC, Da Cruz S, Parone PA, Buchman VL, Ninkina NN. Shelkovnikova TA, et al. Among authors: peters om. J Biol Chem. 2013 Aug 30;288(35):25266-25274. doi: 10.1074/jbc.M113.492017. Epub 2013 Jul 18. J Biol Chem. 2013. PMID: 23867462 Free PMC article.
31 results