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Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Hickey CM, Digianantonio KM, Zimmermann K, Harbin A, Quinn C, Patel A, Gareiss P, Chapman A, Tiberi B, Dobrodziej J, Corradi J, Cacace AM, Langley DR, Békés M. Hickey CM, et al. Nat Struct Mol Biol. 2024 Feb;31(2):311-322. doi: 10.1038/s41594-023-01146-w. Epub 2024 Jan 4. Nat Struct Mol Biol. 2024. PMID: 38177675
Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide.
Hadji A, Schmitt GK, Schnorenberg MR, Roach L, Hickey CM, Leak LB, Tirrell MV, LaBelle JL. Hadji A, et al. Among authors: hickey cm. Oncotarget. 2019 Oct 22;10(58):6219-6233. doi: 10.18632/oncotarget.27262. eCollection 2019 Oct 22. Oncotarget. 2019. PMID: 31692812 Free PMC article.
39 results