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Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients.
Ridnour LA, Cheng RYS, Heinz WF, Pore M, Gonzalez AL, Femino EL, Moffat R, Wink AL, Imtiaz F, Coutinho L, Butcher D, Edmondson EF, Rangel MC, Wong STC, Lipkowitz S, Glynn S, Vitek MP, McVicar DW, Li X, Anderson SK, Paolocci N, Hewitt SM, Ambs S, Billiar TR, Chang JC, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: hewitt sm. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572867. doi: 10.1101/2023.12.21.572867. bioRxiv. 2023. PMID: 38187660 Free PMC article. Preprint.
Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER - Breast Tumors that Lead to Poor Outcome.
Cheng RY, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundarum V, Heinz WF, Coutinho L, Cristina Rangel M, Edmondson EF, Butcher D, Kinders RJ, Li X, Wong STC, McVicar DW, Anderson SK, Pore M, Hewitt SM, Billiar TR, Glynn S, Chang JC, Lockett SJ, Ambs S, Wink DA. Cheng RY, et al. Among authors: hewitt sm. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535916. doi: 10.1101/2023.04.06.535916. bioRxiv. 2023. Update in: Cell Death Dis. 2023 May 11;14(5):319. doi: 10.1038/s41419-023-05834-9 PMID: 37066331 Free PMC article. Updated. Preprint.
NOS2 and COX2 Provide Key Spatial Targets that Determine Outcome in ER- Breast Cancer.
Ridnour LA, Heinz WF, Cheng RY, Wink AL, Kedei N, Pore M, Imtiaz F, Femino EL, Gonzalez AL, Coutinho L, Butcher D, Edmondson EF, Rangel MC, Kinders RJ, Lipkowitz S, Wong ST, Anderson SK, McVicar DW, Li X, Glynn SA, Billiar TR, Chang JC, Hewitt SM, Ambs S, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: hewitt sm. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572859. doi: 10.1101/2023.12.21.572859. bioRxiv. 2023. PMID: 38187532 Free PMC article. Preprint.
Spatial Deconvolution of Cell Types and Cell States at Scale Utilizing TACIT.
Huynh KLA, Tyc KM, Matuck BF, Easter QT, Pratapa A, Kumar NV, Pérez P, Kulchar R, Pranzatelli T, de Souza D, Weaver TM, Qu X, Valente Soares LA, Dolhnokoff M, Kleiner DE, Hewitt SM, da Silva LFF, Rocha VG, Warner BM, Byrd KM, Liu J. Huynh KLA, et al. Among authors: hewitt sm. bioRxiv [Preprint]. 2024 Jun 3:2024.05.31.596861. doi: 10.1101/2024.05.31.596861. bioRxiv. 2024. PMID: 38895230 Free PMC article. Preprint.
SARS-CoV-2 Infection of Salivary Glands Compromises Oral Antifungal Innate Immunity and Predisposes to Oral Candidiasis.
Alfaifi AA, Wang TW, Perez P, Sultan AS, Meiller TF, Rock P, Kleiner DE, Chertow DS, Hewitt SM, Gasmi B, Stein S, Ramelli S, Martin D, Warner BM, Jabra-Rizk MA. Alfaifi AA, et al. Among authors: hewitt sm. bioRxiv [Preprint]. 2024 Jun 11:2024.05.13.593942. doi: 10.1101/2024.05.13.593942. bioRxiv. 2024. PMID: 38798323 Free PMC article. Preprint.
SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis.
Alfaifi AA, Wang TW, Perez P, Sultan AS, Meiller TF, Rock P, Kleiner DE, Chertow DS, Hewitt SM, Gasmi B, Stein S, Ramelli S, Martin D, Warner BM, Jabra-Rizk MA. Alfaifi AA, et al. Among authors: hewitt sm. PLoS Pathog. 2024 Dec 12;20(12):e1012375. doi: 10.1371/journal.ppat.1012375. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39666753 Free PMC article.
Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Ridnour LA, Heinz WF, Cheng RYS, Wink AL, Kedei N, Pore M, Imtiaz F, Femino EL, Gonzalez AL, Coutinho LL, Moffat RL, Butcher D, Edmondson EF, Li X, Rangel MC, Kinders RJ, Rittscher J, Lipkowitz S, Wong STC, Anderson SK, McVicar DW, Glynn SA, Billiar TR, Chang JC, Hewitt SM, Ambs S, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: hewitt sm. Cancer Res Commun. 2024 Oct 1;4(10):2766-2782. doi: 10.1158/2767-9764.CRC-24-0235. Cancer Res Commun. 2024. PMID: 39356141 Free PMC article.
Initiator cell death event induced by SARS-CoV-2 in the human airway epithelium.
Liang K, Barnett KC, Hsu M, Chou WC, Bais SS, Riebe K, Xie Y, Nguyen TT, Oguin TH 3rd, Vannella KM, Hewitt SM, Chertow DS, Blasi M, Sempowski GD, Karlsson A, Koller BH, Lenschow DJ, Randell SH, Ting JP. Liang K, et al. Among authors: hewitt sm. Sci Immunol. 2024 Jul 12;9(97):eadn0178. doi: 10.1126/sciimmunol.adn0178. Epub 2024 Jul 12. Sci Immunol. 2024. PMID: 38996010
435 results