Salphati L - Search Results

1

Preclinical characterization of the absorption and disposition of the brain penetrant PI3K/mTOR inhibitor paxalisib and prediction of its pharmacokinetics and efficacy in human.

Salphati L, Pang J, Alicke B, Plise EG, Cheong J, Jaochico A, Olivero AG, Sampath D, Wong S, Zhang X. Salphati L, et al. Xenobiotica. 2024 Feb;54(2):64-74. doi: 10.1080/00498254.2024.2303586. Epub 2024 Jan 15. Xenobiotica. 2024. PMID: 38197324

2

Highlights From the American Association of Pharmaceutical Scientists/ International Transporter Consortium Joint Workshop on Drug Transporters in Absorption, Distribution, Metabolism, and Excretion: From the Bench to the Bedside - Clinical Pharmacology Considerations.

Ronaldson PT, Bauer B, El-Kattan AF, Shen H, Salphati L, Louie SW. Ronaldson PT, et al. Among authors: salphati l. Clin Pharmacol Ther. 2016 Nov;100(5):419-422. doi: 10.1002/cpt.439. Epub 2016 Sep 13. Clin Pharmacol Ther. 2016. PMID: 27500791 Free PMC article.

3

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. Yago MR, et al. Among authors: salphati l. AAPS J. 2014 Nov;16(6):1358-65. doi: 10.1208/s12248-014-9673-9. Epub 2014 Oct 2. AAPS J. 2014. PMID: 25274610 Free PMC article. Clinical Trial.

4

Active secretion and enterocytic drug metabolism barriers to drug absorption.

Wacher VJ, Salphati L, Benet LZ. Wacher VJ, et al. Among authors: salphati l. Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):89-102. doi: 10.1016/s0169-409x(00)00126-5. Adv Drug Deliv Rev. 2001. PMID: 11259835 Review.

5

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.

Cummins CL, Salphati L, Reid MJ, Benet LZ. Cummins CL, et al. Among authors: salphati l. J Pharmacol Exp Ther. 2003 Apr;305(1):306-14. doi: 10.1124/jpet.102.044719. J Pharmacol Exp Ther. 2003. PMID: 12649383

6

Transport-metabolism interplay.

Salphati L. Salphati L. Mol Pharm. 2009 Nov-Dec;6(6):1629-30. doi: 10.1021/mp900266r. Mol Pharm. 2009. PMID: 19961234 No abstract available.

7

Evaluation of a single-pass intestinal-perfusion method in rat for the prediction of absorption in man.

Salphati L, Childers K, Pan L, Tsutsui K, Takahashi L. Salphati L, et al. J Pharm Pharmacol. 2001 Jul;53(7):1007-13. doi: 10.1211/0022357011776252. J Pharm Pharmacol. 2001. PMID: 11480535

8

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

Salphati L, Benet LZ. Salphati L, et al. Biochem Pharmacol. 1998 Feb 15;55(4):387-95. doi: 10.1016/s0006-2952(97)00436-x. Biochem Pharmacol. 1998. PMID: 9514072

9

Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513.

Salphati L, Plise EG, Li G. Salphati L, et al. Eur J Pharm Sci. 2009 Jun 28;37(3-4):463-8. doi: 10.1016/j.ejps.2009.04.001. Epub 2009 Apr 9. Eur J Pharm Sci. 2009. PMID: 19491037

10

Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitors for the treatment of cancer.

Sutherlin DP, Sampath D, Berry M, Castanedo G, Chang Z, Chuckowree I, Dotson J, Folkes A, Friedman L, Goldsmith R, Heffron T, Lee L, Lesnick J, Lewis C, Mathieu S, Nonomiya J, Olivero A, Pang J, Prior WW, Salphati L, Sideris S, Tian Q, Tsui V, Wan NC, Wang S, Wiesmann C, Wong S, Zhu BY. Sutherlin DP, et al. Among authors: salphati l. J Med Chem. 2010 Feb 11;53(3):1086-97. doi: 10.1021/jm901284w. J Med Chem. 2010. PMID: 20050669

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