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Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies.
Wilder BK, Vigdorovich V, Carbonetti S, Minkah N, Hertoghs N, Raappana A, Cardamone H, Oliver BG, Trakhimets O, Kumar S, Dambrauskas N, Arredondo SA, Camargo N, Seilie AM, Murphy SC, Kappe SHI, Sather DN. Wilder BK, et al. NPJ Vaccines. 2022 May 26;7(1):58. doi: 10.1038/s41541-022-00480-2. NPJ Vaccines. 2022. PMID: 35618791 Free PMC article.
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver.
Franke-Fayard B, Marin-Mogollon C, Geurten FJA, Chevalley-Maurel S, Ramesar J, Kroeze H, Baalbergen E, Wessels E, Baron L, Soulard V, Martinson T, Aleshnick M, Huijs ATG, Subudhi AK, Miyazaki Y, Othman AS, Kolli SK, Lamers OAC, Roques M, Stanway RR, Murphy SC, Foquet L, Moita D, Mendes AM, Prudêncio M, Dechering KJ, Heussler VT, Pain A, Wilder BK, Roestenberg M, Janse CJ. Franke-Fayard B, et al. Among authors: wilder bk. NPJ Vaccines. 2022 Nov 4;7(1):139. doi: 10.1038/s41541-022-00558-x. NPJ Vaccines. 2022. PMID: 36333336 Free PMC article.
Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine.
MacMillen Z, Hatzakis K, Simpson A, Shears MJ, Watson F, Erasmus JH, Khandhar AP, Wilder B, Murphy SC, Reed SG, Davie JW, Avril M. MacMillen Z, et al. Among authors: wilder b. bioRxiv [Preprint]. 2023 May 23:2023.05.23.541932. doi: 10.1101/2023.05.23.541932. bioRxiv. 2023. Update in: NPJ Vaccines. 2024 Jan 10;9(1):12. doi: 10.1038/s41541-023-00799-4 PMID: 37292739 Free PMC article. Updated. Preprint.
Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine.
MacMillen Z, Hatzakis K, Simpson A, Shears M, Watson F, Erasmus J, Khandhar A, Wilder B, Murphy S, Reed S, Davie J, Avril M. MacMillen Z, et al. Among authors: wilder b. Res Sq [Preprint]. 2023 Jun 26:rs.3.rs-3045076. doi: 10.21203/rs.3.rs-3045076/v1. Res Sq. 2023. Update in: NPJ Vaccines. 2024 Jan 10;9(1):12. doi: 10.1038/s41541-023-00799-4 PMID: 37461621 Free PMC article. Updated. Preprint.
Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein.
Dacon C, Moskovitz R, Swearingen K, Da Silva Pereira L, Flores-Garcia Y, Aleshnick M, Kanatani S, Flynn B, Molina-Cruz A, Wollenberg K, Traver M, Kirtley P, Purser L, Dillon M, Bonilla B, Franco A, Petros S, Kritzberg J, Tucker C, Paez GG, Gupta P, Shears MJ, Pazzi J, Edgar JM, Teng AA, Belmonte A, Oda K, Doumbo S, Krymskaya L, Skinner J, Li S, Ghosal S, Kayentao K, Ongoiba A, Vaughan A, Campo JJ, Traore B, Barillas-Mury C, Wijayalath W, Idris A, Crompton PD, Sinnis P, Wilder BK, Zavala F, Seder RA, Wilson IA, Tan J. Dacon C, et al. Among authors: wilder bk. Science. 2025 Jan 3;387(6729):eadr0510. doi: 10.1126/science.adr0510. Epub 2025 Jan 3. Science. 2025. PMID: 39745947
ELQ-331 as a prototype for extremely durable chemoprotection against malaria.
Smilkstein MJ, Pou S, Krollenbrock A, Bleyle LA, Dodean RA, Frueh L, Hinrichs DJ, Li Y, Martinson T, Munar MY, Winter RW, Bruzual I, Whiteside S, Nilsen A, Koop DR, Kelly JX, Kappe SHI, Wilder BK, Riscoe MK. Smilkstein MJ, et al. Malar J. 2019 Aug 27;18(1):291. doi: 10.1186/s12936-019-2921-9. Malar J. 2019. PMID: 31455339 Free PMC article.
Platelet derived growth factor receptor β (PDGFRβ) is a host receptor for the human malaria parasite adhesin TRAP.
Steel RWJ, Vigdorovich V, Dambrauskas N, Wilder BK, Arredondo SA, Goswami D, Kumar S, Carbonetti S, Swearingen KE, Nguyen T, Betz W, Camargo N, Fisher BS, Soden J, Thomas H, Freeth J, Moritz RL, Noah Sather D, Kappe SHI. Steel RWJ, et al. Sci Rep. 2021 May 31;11(1):11328. doi: 10.1038/s41598-021-90722-5. Sci Rep. 2021. PMID: 34059712 Free PMC article.
282 results