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Deterministic reprogramming of neutrophils within tumors.
Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jin J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Liu Z, Duan K, Narang V, Ballesteros I, Moalli F, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh YH, Tey HL, Chong SZ, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG. Ng MSF, et al. Among authors: sharma a. Science. 2024 Jan 12;383(6679):eadf6493. doi: 10.1126/science.adf6493. Epub 2024 Jan 12. Science. 2024. PMID: 38207030 Free PMC article.
Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma.
Sharma A, Seow JJW, Dutertre CA, Pai R, Blériot C, Mishra A, Wong RMM, Singh GSN, Sudhagar S, Khalilnezhad S, Erdal S, Teo HM, Khalilnezhad A, Chakarov S, Lim TKH, Fui ACY, Chieh AKW, Chung CP, Bonney GK, Goh BK, Chan JKY, Chow PKH, Ginhoux F, DasGupta R. Sharma A, et al. Cell. 2020 Oct 15;183(2):377-394.e21. doi: 10.1016/j.cell.2020.08.040. Epub 2020 Sep 24. Cell. 2020. PMID: 32976798 Free article.
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction.
Seow JJW, Pai R, Mishra A, Shepherdson E, Lim TKH, Goh BKP, Chan JKY, Chow PKH, Ginhoux F, DasGupta R, Sharma A. Seow JJW, et al. Among authors: sharma a. Front Med (Lausanne). 2021 Apr 22;8:603374. doi: 10.3389/fmed.2021.603374. eCollection 2021. Front Med (Lausanne). 2021. PMID: 33968947 Free PMC article.
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease.
Mulder K, Patel AA, Kong WT, Piot C, Halitzki E, Dunsmore G, Khalilnezhad S, Irac SE, Dubuisson A, Chevrier M, Zhang XM, Tam JKC, Lim TKH, Wong RMM, Pai R, Khalil AIS, Chow PKH, Wu SZ, Al-Eryani G, Roden D, Swarbrick A, Chan JKY, Albani S, Derosa L, Zitvogel L, Sharma A, Chen J, Silvin A, Bertoletti A, Blériot C, Dutertre CA, Ginhoux F. Mulder K, et al. Among authors: sharma a. Immunity. 2021 Aug 10;54(8):1883-1900.e5. doi: 10.1016/j.immuni.2021.07.007. Epub 2021 Jul 30. Immunity. 2021. PMID: 34331874 Free article.
A subset of Kupffer cells regulates metabolism through the expression of CD36.
Blériot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F. Blériot C, et al. Among authors: sharma a. Immunity. 2021 Sep 14;54(9):2101-2116.e6. doi: 10.1016/j.immuni.2021.08.006. Epub 2021 Aug 31. Immunity. 2021. PMID: 34469775 Free article.
Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy.
Li Z, Pai R, Gupta S, Currenti J, Guo W, Di Bartolomeo A, Feng H, Zhang Z, Li Z, Liu L, Singh A, Bai Y, Yang B, Mishra A, Yang K, Qiao L, Wallace M, Yin Y, Xia Q, Chan JKY, George J, Chow PK, Ginhoux F, Sharma A. Li Z, et al. Among authors: sharma a. Nat Cancer. 2024 Jan;5(1):167-186. doi: 10.1038/s43018-023-00672-2. Epub 2024 Jan 2. Nat Cancer. 2024. PMID: 38168935
Timing and location dictate monocyte fate and their transition to tumor-associated macrophages.
Dunsmore G, Guo W, Li Z, Bejarano DA, Pai R, Yang K, Kwok I, Tan L, Ng M, De La Calle Fabregat C, Yatim A, Bougouin A, Mulder K, Thomas J, Villar J, Bied M, Kloeckner B, Dutertre CA, Gessain G, Chakarov S, Liu Z, Scoazec JY, Lennon-Dumenil AM, Marichal T, Sautès-Fridman C, Fridman WH, Sharma A, Su B, Schlitzer A, Ng LG, Blériot C, Ginhoux F. Dunsmore G, et al. Among authors: sharma a. Sci Immunol. 2024 Jul 26;9(97):eadk3981. doi: 10.1126/sciimmunol.adk3981. Epub 2024 Jul 26. Sci Immunol. 2024. PMID: 39058763
Taurine deficiency as a driver of aging.
Singh P, Gollapalli K, Mangiola S, Schranner D, Yusuf MA, Chamoli M, Shi SL, Lopes Bastos B, Nair T, Riermeier A, Vayndorf EM, Wu JZ, Nilakhe A, Nguyen CQ, Muir M, Kiflezghi MG, Foulger A, Junker A, Devine J, Sharan K, Chinta SJ, Rajput S, Rane A, Baumert P, Schönfelder M, Iavarone F, di Lorenzo G, Kumari S, Gupta A, Sarkar R, Khyriem C, Chawla AS, Sharma A, Sarper N, Chattopadhyay N, Biswal BK, Settembre C, Nagarajan P, Targoff KL, Picard M, Gupta S, Velagapudi V, Papenfuss AT, Kaya A, Ferreira MG, Kennedy BK, Andersen JK, Lithgow GJ, Ali AM, Mukhopadhyay A, Palotie A, Kastenmüller G, Kaeberlein M, Wackerhage H, Pal B, Yadav VK. Singh P, et al. Among authors: sharma a. Science. 2023 Jun 9;380(6649):eabn9257. doi: 10.1126/science.abn9257. Epub 2023 Jun 9. Science. 2023. PMID: 37289866 Free PMC article.
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