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IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells.
Rai S, Zhang Y, Grockowiak E, Kimmerlin Q, Hansen N, Stoll CB, Usart M, Luque Paz D, Hao-Shen H, Zhu Y, Roux J, Bader MS, Dirnhofer S, Farady CJ, Schroeder T, Méndez-Ferrer S, Skoda RC. Rai S, et al. Among authors: zhang y. Blood Adv. 2024 Mar 12;8(5):1234-1249. doi: 10.1182/bloodadvances.2023011338. Blood Adv. 2024. PMID: 38207211 Free PMC article.
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jäger Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Adams R, Schroeder T, Rieger MA, Offermanns S. Le Mercier A, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2021596118. doi: 10.1073/pnas.2021596118. Proc Natl Acad Sci U S A. 2021. PMID: 33875597 Free PMC article.
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