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Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition.
Luo H, Chen J, Li C, Wu T, Yin S, Yang G, Wang Y, Guo Z, Hu S, He Y, Wang Y, Chen Y, Su Y, Miao C, Qian Y, Feng R. Luo H, et al. Among authors: feng r. Clin Transl Med. 2025 Jan;15(1):e70193. doi: 10.1002/ctm2.70193. Clin Transl Med. 2025. PMID: 39834092 Free PMC article.
3,196 results