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The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL; MACS/WIHS combined cohort study (MWCSS). Shahid A, et al. Among authors: maclennan s. J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214547 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobamibias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL. Shahid A, et al. Among authors: maclennan s. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3259040. doi: 10.21203/rs.3.rs-3259040/v1. Res Sq. 2023. Update in: J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23 PMID: 37645749 Free PMC article. Updated. Preprint.
A simple phylogenetic approach to analyze hypermutated HIV proviruses reveals insights into their dynamics and persistence during antiretroviral therapy.
Shahid A, Jones BR, Duncan MC, MacLennan S, Dapp MJ, Kuniholm MH, Aouizerat B, Archin NM, Gange S, Ofotokun I, Fischl MA, Kassaye S, Goldstein H, Anastos K, Joy JB, Brumme ZL. Shahid A, et al. Among authors: maclennan s. Res Sq [Preprint]. 2024 Jun 13:rs.3.rs-4549934. doi: 10.21203/rs.3.rs-4549934/v1. Res Sq. 2024. PMID: 38947061 Free PMC article. Preprint.
Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.
Porter VL, Ng M, O'Neill K, MacLennan S, Corbett RD, Culibrk L, Hamadeh Z, Iden M, Schmidt R, Tsaih SW, Nakisige C, Origa M, Orem J, Chang G, Fan J, Nip KM, Akbari V, Chan SK, Hopkins J, Moore RA, Chuah E, Mungall KL, Mungall AJ, Birol I, Jones SJM, Rader JS, Marra MA. Porter VL, et al. Among authors: maclennan s. Genome Res. 2024 Dec 5:gr.279041.124. doi: 10.1101/gr.279041.124. Online ahead of print. Genome Res. 2024. PMID: 39638560 Free article.
CATHETER II: a randomised controlled trial comparing the clinical effectiveness of various washout policies versus no washout policy in preventing catheter-associated complications in adults living with long-term catheters.
Abdel-Fattah M, Omar MI, Johnson D, Cooper D, Constable L, Tripathee S, MacLennan SJ, Dimitropoulos K, Evans S, Hashim H, Kilonzo M, Larcombe J, Little P, Murchie P, Myint PK, N'Dow J, Paterson C, Powell K, Scotland G, Thiruchelvam N, Young A, Cotton S, Norrie J, MacLennan G. Abdel-Fattah M, et al. Among authors: maclennan sj. BMJ Open. 2024 Dec 2;14(12):e087203. doi: 10.1136/bmjopen-2024-087203. BMJ Open. 2024. PMID: 39622574 Free PMC article. Clinical Trial.
AGREE II Quality Assessment of National and International Clinical Practice Guidelines on Prostate Cancer Management by the OPTIMA Consortium.
Sakalis V, Bhattacharya Y, Beyer K, Murray C, Smith EJ, Willemse PM, Gandaglia G, Boissier R, Borkowetz A, Dabestani S, Leenen RCA, Vilaseca A, Maresca G, Teoh J, Gómez Rivas J, Rajwa P, Lardas M, Grivas N, Van den Broeck T, Pradere B, Schouten N, Tandogdu Z, Evans-Axelsson S, Maclennan S, Thomas M, Briganti A, Bjartell A, Cornford P, Kruger H, N'Dow J, Roobol MJ, Omar MI; OPTIMA Consortium. Sakalis V, et al. Among authors: maclennan s. Eur Urol Open Sci. 2024 Nov 12;70:183-193. doi: 10.1016/j.euros.2024.10.020. eCollection 2024 Dec. Eur Urol Open Sci. 2024. PMID: 39611162 Free PMC article. Review.
Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes.
O'Neill K, Pleasance E, Fan J, Akbari V, Chang G, Dixon K, Csizmok V, MacLennan S, Porter V, Galbraith A, Grisdale CJ, Culibrk L, Dupuis JH, Corbett R, Hopkins J, Bowlby R, Pandoh P, Smailus DE, Cheng D, Wong T, Frey C, Shen Y, Lewis E, Paulin LF, Sedlazeck FJ, Nelson JMT, Chuah E, Mungall KL, Moore RA, Coope R, Mungall AJ, McConechy MK, Williamson LM, Schrader KA, Yip S, Marra MA, Laskin J, Jones SJM. O'Neill K, et al. Among authors: maclennan s. Cell Genom. 2024 Nov 13;4(11):100674. doi: 10.1016/j.xgen.2024.100674. Epub 2024 Oct 14. Cell Genom. 2024. PMID: 39406235 Free PMC article.
262 results