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A safe, effective and adaptable live-attenuated SARS-CoV-2 vaccine to reduce disease and transmission using one-to-stop genome modifications.
Schön J, Barut GT, Trüeb BS, Halwe NJ, Berenguer Veiga I, Kratzel A, Ulrich L, Kelly JN, Brügger M, Wylezich C, Taddeo A, Aguiar Moreira E, Túrós D, Grau-Roma L, Ahrens AK, Schlottau K, Britzke T, Breithaupt A, Corleis B, Kochmann J, Oliveira Esteves BI, Almeida L, Thomann L, Devisme C, Stalder H, Steiner S, Ochsenbein S, Schmied K, Labroussaa F, Jores J, V'kovski P, Cmiljanovic V, Alves MP, Benarafa C, Ebert N, Hoffmann D, Beer M, Thiel V. Schön J, et al. Among authors: kratzel a. Nat Microbiol. 2024 Aug;9(8):2099-2112. doi: 10.1038/s41564-024-01755-1. Epub 2024 Jul 12. Nat Microbiol. 2024. PMID: 38997518 Free PMC article.
SARS-CoV-2 biology and host interactions.
Steiner S, Kratzel A, Barut GT, Lang RM, Aguiar Moreira E, Thomann L, Kelly JN, Thiel V. Steiner S, et al. Among authors: kratzel a. Nat Rev Microbiol. 2024 Apr;22(4):206-225. doi: 10.1038/s41579-023-01003-z. Epub 2024 Jan 15. Nat Rev Microbiol. 2024. PMID: 38225365 Review.
The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype.
Barut GT, Halwe NJ, Taddeo A, Kelly JN, Schön J, Ebert N, Ulrich L, Devisme C, Steiner S, Trüeb BS, Hoffmann B, Veiga IB, Leborgne NGF, Moreira EA, Breithaupt A, Wylezich C, Höper D, Wernike K, Godel A, Thomann L, Flück V, Stalder H, Brügger M, Esteves BIO, Zumkehr B, Beilleau G, Kratzel A, Schmied K, Ochsenbein S, Lang RM, Wider M, Machahua C, Dorn P, Marti TM, Funke-Chambour M, Rauch A, Widera M, Ciesek S, Dijkman R, Hoffmann D, Alves MP, Benarafa C, Beer M, Thiel V. Barut GT, et al. Among authors: kratzel a. Nat Commun. 2022 Oct 7;13(1):5929. doi: 10.1038/s41467-022-33632-y. Nat Commun. 2022. PMID: 36207334 Free PMC article.
Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits.
Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, Tropia L, Gorgulla C, Arthanari H, Thiel V, Mohr P, Gamboni R, Halazonetis TD. Rossetti GG, et al. Among authors: kratzel a. Sci Rep. 2022 Feb 15;12(1):2505. doi: 10.1038/s41598-022-06306-4. Sci Rep. 2022. PMID: 35169179 Free PMC article.
A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets.
Kratzel A, Kelly JN, V'kovski P, Portmann J, Brüggemann Y, Todt D, Ebert N, Shrestha N, Plattet P, Staab-Weijnitz CA, von Brunn A, Steinmann E, Dijkman R, Zimmer G, Pfaender S, Thiel V. Kratzel A, et al. PLoS Biol. 2021 Dec 28;19(12):e3001490. doi: 10.1371/journal.pbio.3001490. eCollection 2021 Dec. PLoS Biol. 2021. PMID: 34962926 Free PMC article.
Susceptibility of Well-Differentiated Airway Epithelial Cell Cultures from Domestic and Wild Animals to Severe Acute Respiratory Syndrome Coronavirus 2.
Gultom M, Licheri M, Laloli L, Wider M, Strässle M, V'kovski P, Steiner S, Kratzel A, Thao TTN, Probst L, Stalder H, Portmann J, Holwerda M, Ebert N, Stokar-Regenscheit N, Gurtner C, Zanolari P, Posthaus H, Schuller S, Vicente-Santos A, Moreira-Soto A, Corrales-Aguilar E, Ruggli N, Tekes G, von Messling V, Sawatsky B, Thiel V, Dijkman R. Gultom M, et al. Among authors: kratzel a. Emerg Infect Dis. 2021 Jul;27(7):1811-1820. doi: 10.3201/eid2707.204660. Emerg Infect Dis. 2021. PMID: 34152956 Free PMC article.
20 results