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Pharmacokinetics, Disposition, and Biotransformation of [14C]Lenacapavir, a Novel, First-in-Class, Selective Inhibitor of HIV-1 Capsid Function, in Healthy Participants Following a Single Intravenous Infusion.
Weber E, Subramanian R, Rowe W, Graupe M, Ling J, Shen G, Begley R, Sager J, Wolckenhauer S, Rhee M, Palaparthy R, Singh R. Weber E, et al. Among authors: singh r. Clin Pharmacokinet. 2024 Feb;63(2):241-253. doi: 10.1007/s40262-023-01328-1. Epub 2024 Jan 18. Clin Pharmacokinet. 2024. PMID: 38236562
Lenacapavir: A Novel, Potent, and Selective First-in-Class Inhibitor of HIV-1 Capsid Function Exhibits Optimal Pharmacokinetic Properties for a Long-Acting Injectable Antiretroviral Agent.
Subramanian R, Tang J, Zheng J, Lu B, Wang K, Yant SR, Stepan GJ, Mulato A, Yu H, Schroeder S, Shaik N, Singh R, Wolckenhauer S, Chester A, Tse WC, Chiu A, Rhee M, Cihlar T, Rowe W, Smith BJ. Subramanian R, et al. Among authors: singh r. Mol Pharm. 2023 Dec 4;20(12):6213-6225. doi: 10.1021/acs.molpharmaceut.3c00626. Epub 2023 Nov 2. Mol Pharm. 2023. PMID: 37917742 Free PMC article.
Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.
Sharma KB, Subramani C, Ganesh K, Sharma A, Basu B, Balyan S, Sharma G, Ka S, Deb A, Srivastava M, Chugh S, Sehrawat S, Bharadwaj K, Rout A, Sahoo PK, Saurav S, Motiani RK, Singh R, Jain D, Asthana S, Wadhwa R, Vrati S. Sharma KB, et al. Among authors: singh r. PLoS Pathog. 2024 Dec 30;20(12):e1012816. doi: 10.1371/journal.ppat.1012816. Online ahead of print. PLoS Pathog. 2024. PMID: 39775571
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