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116 results

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A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting.
Fuat A, Adlen E, Monane M, Coll R, Groves S, Little E, Wild J, Kamali FJ, Soni Y, Haining S, Riding H, Riveros-Mckay F, Peneva I, Lachapelle A, Giner-Delgado C, Weale ME, Plagnol V, Harrison S, Donnelly P. Fuat A, et al. Among authors: weale me. Eur J Prev Cardiol. 2024 Apr 18;31(6):716-722. doi: 10.1093/eurjpc/zwae004. Eur J Prev Cardiol. 2024. PMID: 38243727
Polygenic risk score adds to a clinical risk score in the prediction of cardiovascular disease in a clinical setting.
Samani NJ, Beeston E, Greengrass C, Riveros-McKay F, Debiec R, Lawday D, Wang Q, Budgeon CA, Braund PS, Bramley R, Kharodia S, Newton M, Marshall A, Krzeminski A, Zafar A, Chahal A, Heer A, Khunti K, Joshi N, Lakhani M, Farooqi A, Plagnol V, Donnelly P, Weale ME, Nelson CP. Samani NJ, et al. Among authors: weale me. Eur Heart J. 2024 Sep 7;45(34):3152-3160. doi: 10.1093/eurheartj/ehae342. Eur Heart J. 2024. PMID: 38848106 Free PMC article.
A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.
Thompson DJ, Wells D, Selzam S, Peneva I, Moore R, Sharp K, Tarran WA, Beard EJ, Riveros-Mckay F, Giner-Delgado C, Palmer D, Seth P, Harrison J, Futema M; Genomics England Research Consortium; McVean G, Plagnol V, Donnelly P, Weale ME. Thompson DJ, et al. Among authors: weale me. PLoS One. 2024 Sep 18;19(9):e0307270. doi: 10.1371/journal.pone.0307270. eCollection 2024. PLoS One. 2024. PMID: 39292644 Free PMC article.
Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture.
Bird N, Ormond L, Awah P, Caldwell EF, Connell B, Elamin M, Fadlelmola FM, Matthew Fomine FL, López S, MacEachern S, Moñino Y, Morris S, Näsänen-Gilmore P, Nketsia V NK, Veeramah K, Weale ME, Zeitlyn D, Thomas MG, Bradman N, Hellenthal G. Bird N, et al. Among authors: weale me. Sci Adv. 2023 Mar 29;9(13):eabq2616. doi: 10.1126/sciadv.abq2616. Epub 2023 Mar 29. Sci Adv. 2023. PMID: 36989356 Free PMC article.
Validation of an Integrated Risk Tool, Including Polygenic Risk Score, for Atherosclerotic Cardiovascular Disease in Multiple Ethnicities and Ancestries.
Weale ME, Riveros-Mckay F, Selzam S, Seth P, Moore R, Tarran WA, Gradovich E, Giner-Delgado C, Palmer D, Wells D, Saffari A, Sivley RM, Lachapelle AS, Wand H, Clarke SL, Knowles JW, O'Sullivan JW, Ashley EA, McVean G, Plagnol V, Donnelly P. Weale ME, et al. Am J Cardiol. 2021 Jun 1;148:157-164. doi: 10.1016/j.amjcard.2021.02.032. Epub 2021 Mar 3. Am J Cardiol. 2021. PMID: 33675770 Free article.
Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction.
Riveros-Mckay F, Weale ME, Moore R, Selzam S, Krapohl E, Sivley RM, Tarran WA, Sørensen P, Lachapelle AS, Griffiths JA, Saffari A, Deanfield J, Spencer CCA, Hippisley-Cox J, Hunter DJ, O'Sullivan JW, Ashley EA, Plagnol V, Donnelly P. Riveros-Mckay F, et al. Among authors: weale me. Circ Genom Precis Med. 2021 Apr;14(2):e003304. doi: 10.1161/CIRCGEN.120.003304. Epub 2021 Mar 2. Circ Genom Precis Med. 2021. PMID: 33651632 Free PMC article.
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.
Mencacci NE, Reynolds R, Ruiz SG, Vandrovcova J, Forabosco P, Sánchez-Ferrer A, Volpato V; UK Brain Expression Consortium; International Parkinson’s Disease Genomics Consortium; Weale ME, Bhatia KP, Webber C, Hardy J, Botía JA, Ryten M. Mencacci NE, et al. Among authors: weale me. Brain. 2020 Sep 1;143(9):2771-2787. doi: 10.1093/brain/awaa217. Brain. 2020. PMID: 32889528 Free PMC article.
Regulatory sites for splicing in human basal ganglia are enriched for disease-relevant information.
Guelfi S, D'Sa K, Botía JA, Vandrovcova J, Reynolds RH, Zhang D, Trabzuni D, Collado-Torres L, Thomason A, Quijada Leyton P, Gagliano Taliun SA, Nalls MA; International Parkinson’s Disease Genomics Consortium (IPDGC); UK Brain Expression Consortium (UKBEC); Small KS, Smith C, Ramasamy A, Hardy J, Weale ME, Ryten M. Guelfi S, et al. Among authors: weale me. Nat Commun. 2020 Feb 25;11(1):1041. doi: 10.1038/s41467-020-14483-x. Nat Commun. 2020. PMID: 32098967 Free PMC article.
Gene Variants at Loci Related to Blood Pressure Account for Variation in Response to Antihypertensive Drugs Between Black and White Individuals.
Iniesta R, Campbell D, Venturini C, Faconti L, Singh S, Irvin MR, Cooper-DeHoff RM, Johnson JA, Turner ST, Arnett DK, Weale ME, Warren H, Munroe PB, Cruickshank K, Padmanabhan S, Lewis C, Chowienczyk P. Iniesta R, et al. Among authors: weale me. Hypertension. 2019 Sep;74(3):614-622. doi: 10.1161/HYPERTENSIONAHA.118.12177. Epub 2019 Jul 22. Hypertension. 2019. PMID: 31327267
116 results