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NHE3 inhibitor tenapanor maintains intestinal barrier function, decreases visceral hypersensitivity, and attenuates TRPV1 signaling in colonic sensory neurons.
King AJ, Chang L, Li Q, Liu L, Zhu Y, Pasricha PJ, Wang J, Siegel M, Caldwell JS, Edelstein S, Rosenbaum DP, Kozuka K. King AJ, et al. Among authors: chang l. Am J Physiol Gastrointest Liver Physiol. 2024 May 1;326(5):G543-G554. doi: 10.1152/ajpgi.00233.2023. Epub 2024 Jan 22. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 38252683 Free PMC article.
Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation.
Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Videlock EJ, et al. Among authors: chang l. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157. doi: 10.1152/ajpgi.00288.2017. Epub 2018 Mar 22. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29565640 Free PMC article.
Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome.
Choo C, Mahurkar-Joshi S, Dong TS, Lenhart A, Lagishetty V, Jacobs JP, Labus JS, Jaffe N, Mayer EA, Chang L. Choo C, et al. Among authors: chang l. Am J Physiol Gastrointest Liver Physiol. 2022 Aug 1;323(2):G134-G143. doi: 10.1152/ajpgi.00352.2021. Epub 2022 Jun 21. Am J Physiol Gastrointest Liver Physiol. 2022. PMID: 35726867 Free PMC article.
Abdominal Symptom Improvement During Clinical Trials of Tenapanor in Patients With Irritable Bowel Syndrome With Constipation: A Post Hoc Analysis.
Lembo AJ, Chey WD, Harris LA, Frazier R, Brenner DM, Chang L, Lacy BE, Edelstein S, Yang Y, Zhao S, Rosenbaum DP. Lembo AJ, et al. Among authors: chang l. Am J Gastroenterol. 2024 May 1;119(5):937-945. doi: 10.14309/ajg.0000000000002685. Epub 2024 Jan 31. Am J Gastroenterol. 2024. PMID: 38294158 Free PMC article. Clinical Trial.
V. Stress and irritable bowel syndrome.
Mayer EA, Naliboff BD, Chang L, Coutinho SV. Mayer EA, et al. Among authors: chang l. Am J Physiol Gastrointest Liver Physiol. 2001 Apr;280(4):G519-24. doi: 10.1152/ajpgi.2001.280.4.G519. Am J Physiol Gastrointest Liver Physiol. 2001. PMID: 11254476 Free article. Review.
Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity.
Strege PR, Mazzone A, Bernard CE, Neshatian L, Gibbons SJ, Saito YA, Tester DJ, Calvert ML, Mayer EA, Chang L, Ackerman MJ, Beyder A, Farrugia G. Strege PR, et al. Among authors: chang l. Am J Physiol Gastrointest Liver Physiol. 2018 Apr 1;314(4):G494-G503. doi: 10.1152/ajpgi.00016.2017. Epub 2017 Nov 22. Am J Physiol Gastrointest Liver Physiol. 2018. PMID: 29167113 Free PMC article.
9,617 results